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Search results for:
bevacizumab
bevacizumab
Brand names: Alymsys, Avastin, Mvasi, Vegzelma, Zirabev
| Form | Strength | ANAN | ASMP | LACH | LALK | LOHH | LOLR | LOWC | SDSD | SESE | SFSF | Formulary Status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SOLUTION, INTRAVENOUS | 25 mg/mL; adcd 25 mg/mL; awwb 25 mg/mL; bvzr 25 mg/mL; maly 25 mg/mL | Ophthalmic & recurrent respiratory papillomatosis use exceptions for Avastin |
Last updated: Oct. 4, 2024
- Black Box Warning: GI perforation; wound healing complications
- Therapeutic Interchange: Biosimilar and Reference Products Conversion List for Adults
- Do Not Tube-LALK
Chemotherapy Chart
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines
(Note: “Therapeutic Interchange” should be placed in the order comments)
**Exceptions: Avastin is the only bevacizumab product with off-label approval for intravitreal administration in ophthalmic indications. Avastin (only) is approved for intralesional/intralaryngeal injections for recurrent respiratory papillomatosis.**
Biosimilar and Reference Products Interchange List for Adults
Medication
Reference Drug or Biosimilar
Formulary Status
Automatic Therapeutic Interchange
Inpatient1
Outpatient
*New Starts/New Authorizations Only*
Zirabev (bevacizumab-bvzr)
Biosimilar
Formulary
Use Zirabev
Interchange to Mvasi unless third party payer requires other bevacizumab product
Mvasi (bevacizumab-awwb)
Biosimilar
Formulary, restricted to OP
(preferred)
Interchange to Zirabev
Use Mvasi unless third party payer requires other bevacizumab product
Alymsys (bevacizumab-maly)
Vegzelma (bevacizumab-adcd)
Biosimilars
Formulary, restricted to OP
(not preferred)
Interchange to Zirabev
Interchange to Mvasi unless third party payer requires other bevacizumab product
Avastin (bevacizumab)
Reference
Formulary, restricted to OP (not preferred), for intravitreal administration, and intralesional/intralaryngeal for recurrent respiratory papillomatosis only
Interchange to Zirabev *unless for approved intravitreal or intralesional/intralaryngeal use*
Interchange to Mvasi unless third party payer requires other bevacizumab product or for intravitreal route (ophthalmic use) / intralesional/intralaryngeal route (recurrent respiratory papillomatosis use)
Hepatocellular cancer approval: only Avastin is FDA approved. However, NCCN Guidelines for Hepatocellular Carcinoma state: “an FDA-approved biosimilar is an appropriate substitute for bevacizumab.” Avastin is the only bevacizumab product with off-label approval for intravitreal administration in ophthalmic indications. Avastin (only) is approved for intralesional/intralaryngeal injections for recurrent respiratory papillomatosis.