Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines (Note: “Therapeutic Interchange” should be placed in the order comments)
Quetiapine XR Formulations (as of 8/23)
Medication Ordered
Brand Name
Dosage form
Dose and Frequency
Formulary Medication
Dosage Form
Dose and Frequency
Quetiapine IR
Seroquel
Tablets
FORMULARY AGENT
Quetiapine XR
Seroquel XR
Tablets
50 mg daily
Quetiapine IR
Tablets
25 mg BID
Quetiapine XR
Seroquel XR
Tablets
150 mg daily
Quetiapine IR
Tablets
75 mg BID
Quetiapine XR
Seroquel XR
Tablets
200 mg daily
Quetiapine IR
Tablets
100 mg BID
Quetiapine XR
Seroquel XR
Tablets
300 mg daily
Quetiapine IR
Tablets
150 mg BID
Quetiapine XR
Seroquel XR
Tablets
400 mg daily
Quetiapine IR
Tablets
200 mg BID
Note: Divide the total daily dose into twice daily dosing of regular release quetiapine for other doses as well.
If an at increased risk for sedation and/or postural hypotension, may suggest to the physician to split the dose with a low dose in the AM and the higher dose in the evening
i.e. Patient on quetiapine XL 200mg à quetiapine 50mg AM, 150mg PM
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines
(Note: “Therapeutic Interchange” should be placed in the order comments)
Quetiapine XR Formulations (as of 8/23)
Medication Ordered
Brand Name
Dosage form
Dose and Frequency
Formulary Medication
Dosage Form
Dose and Frequency
Quetiapine IR
Seroquel
Tablets
FORMULARY AGENT
Quetiapine XR
Seroquel XR
Tablets
50 mg daily
Quetiapine IR
Tablets
25 mg BID
Quetiapine XR
Seroquel XR
Tablets
150 mg daily
Quetiapine IR
Tablets
75 mg BID
Quetiapine XR
Seroquel XR
Tablets
200 mg daily
Quetiapine IR
Tablets
100 mg BID
Quetiapine XR
Seroquel XR
Tablets
300 mg daily
Quetiapine IR
Tablets
150 mg BID
Quetiapine XR
Seroquel XR
Tablets
400 mg daily
Quetiapine IR
Tablets
200 mg BID
Note: Divide the total daily dose into twice daily dosing of regular release quetiapine for other doses as well.
i.e. Patient on quetiapine XL 200mg à quetiapine 50mg AM, 150mg PM
Those at possible risk include:
Elderly
Concurrent CNS depressants