SMH 2013 Antibiogram 

SMH Antimicrobial Formulary

Antibacterial Agents – Systemic

Antifungal Agents – Systemic

Antiviral Agents – Systemic

Anti-infective Agents – Ear and Eye

Anti-infective Agents – Topical and Vaginal   

Automatic IV-to-Oral Conversion Program (SMH)

Automatic Therapeutic Substitutions

Penicillins

Fluoroquinolones

Clostridium difficile Diarrhea Treatment

Colistin Dosing

Doripenem (Doribax) Dosing

Piperacillin-Tazobactam (Zosyn) Dosing

Vancomycin IV Dosing Guidelines

SMH Antimicrobial Stewardship Program (ASP)

2013 Daptomycin (Cubicin) Usage compared to 2012

2013 Carbapenem Usage compared to 2012

2013 Piperacillin-Tazobactam (Zosyn) Usage compared to 2012

Extended Infusion of Piperacillin-Tazobactam (Zosyn) Drug Studies:

• Shea KM, Cheatham SC, et al. Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. 2009 - Among the results found:  The Cummulative Fraction of Response for 3.375 gm every 8 hours given over 4 hours was comparable to 4.5 gm every 6 hours given over 30 minutes.
• Lodise TP, Lomaestro B, Drusano, G. Piperacillin-tazobactam for Pseudomonas aeruginosa infection: Clinical implications of an extendedinfusion dosing strategy. 2007 - This study found that the sickest patients (patients with APACHE II score > 17 had lower 14-day mortality (31.6% vs 12.2%, p=.04) and shorter median LOS (21 days vs 38 days, p=.02) in the extended infusion arm compared to the 30-minute infusion arm. 

Antimicrobial Prophylaxis for Surgery (IDSA)

Antimicrobial Selection Chart  - Quick Reference for selection of antimicrobial agent for Gram negative and positive organisms divided by morphology (Pharmacy Practice News 2011)

Antimicrobial Stewardship (IDSA)

Table 1:  Antimicrobial Dosing and Redosing

Table 2:  Recommended Antimicrobial Agents by Type of Surgery

CORE Measures

Community-acquired Pneumonia (CAP)

Surgical Prophylaxis (SCIP)

Gentamicin and Tobramycin Adult Dosing Guidelines, Conventional – from University of Medicine and Dentistry in Newark, NJ

Gentamicin and Tobramycin Adult Dosing Guidelines, Extended-Interval – from University of Medicine and Dentistry in Newark, NJ

Guidelines to Microbiology Laboratory for Diagnosis of Infectious Diseases (IDSA)

Infectious Disease Society of America (IDSA) Practice Guidelines

Johns Hopkins Antibiotic Guide

Neutropenic Patients with Cancer (IDSA)

Renal Dosing Adjustments for Antimicrobials

Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy

Vancomycin Therapeutic Monitoring – ISMP 2009

Antibiotic Pharmacokinetic Monitoring – ASHP 2011