IV Product Preparation
Dilution and Stability Guidelines
Memorial Hospital Pharmacy Department
Agent |
Size/Diluents |
Stability Mixed or Opened Vial
|
Final Concentration /Diluents |
Stability CRT/FRG |
Comments |
Acetylcysteine I.V. (Mucomyst) |
6 g/30 ml SW |
|
See Comments |
24 hrs/NA |
LD: 150mg/kg in 200 ml IV over 1 hr 2nd Dose: 50mg/kg in 500 ml IV over 4 hrs. 3rd Dose: 100mg/kg in 1000 ml IV over 16 hrs. Neb solution is stable for 96 hrs in FRI. PI |
Acyclovir (Zovirax) |
500 mg/10 ml SW 1000 mg/20 ml SW |
12hrs |
< 500 mg in 100 ml > 500 mg in 250 ml In D5W or NS |
48 hrs/DNR |
May cause precipitation if refrigerated; product will re-solubilize at room temperature without loss of potency. Recommended conc. <7mg/ml. *TR#8-9, USPL |
Allopurinol (Aloprim) |
500 mg/25 ml SW |
10 hrs (CRT) |
≤ 6 mg/ml in D5W or NS |
10 hrs/DNR |
Do not refrigerate. Swirl, don’t shake. TR#21 |
Alteplase(TPA) |
50 mg/50 ml SW 100mg/100 ml SW 2mg/2 ml SW |
8 hrs(CRT) |
1mg/ml in syringe 5-10mg in 500 ml in NS |
24 hrs/24 hrs |
Frozen syringe is stable for 45 days TR#28-29, USP |
Amikacin (Amikin) |
|
|
<500 mg in 100ml >500 mg in 250ml In NS or D5W |
48 hrs/14 days |
Discoloration may occur due to oxidation without loss of potency TR#37-38, USPL
|
Aminocaproic Acid (Amicar) |
|
|
1 g per 50ml In NS or D5W |
48 hrs/7 days |
More than 30gms over a 24 hrs period not advised. Yellow discoloration occurs after 24 hrs at 23°C without loss of potency. Acceptable conc. range s 10-45 mg/ml . * TR 91, USPL |
Aminophylline (Theophylline) |
|
|
0-250mg /50 ml 251-500 mg/ 100ml in D5W/NS 1mg/ml D5W500 ml(PRE-MIX) |
48hrs/DNR |
TR#93-94, Do not refrigerate(risk of crystallization)
|
Amiodarone (Cordarone) |
|
|
Loading dose = 150 mg in 100 ml D5W |
2 hrs/DNR |
Discard bolus if not used (stable 2hrs). Retain opened vial in carton until contents used. |
Standard Infusion = 500 mg in 500 ml D5W Max 6 mg/ml |
24 hrs/DNR |
Prepare drip in glass bottle or VisIV. Do not use evacuated glass. Conc>2 mg/ml need central line. Use in-line filter. NS can be use but only for 1.8 or 2 mg/ml (Amiodarone precipitation in NS due to salting out has been reported at a lower amiodarone hydrochloride concentration.). TR#104-105,CP |
|||
Amphotericin B (Fungizone) |
50 mg/10 ml SW(use preservative free) |
7 days (4°C) 24 hrs (CRT) if protected from light |
<0.1mg/ml(peripheral) <0.25mg/ml(central and fluid restriction)* In D5W |
24 hrs/24 hrs |
Protect from light. Do Not Mix in NS *Uptodate Use in-line filter(minimum 1 micron), IM#106-107, |
Amphotericin B Lipid Complex (Abelcet) |
|
|
Final con. 1-2mg/ml Diluents D5W |
6 hrs/48 hrs |
Intact vials protect from light, keep refrigerate. Use 5-micron filter needle. PI |
Agent |
Size/Diluents |
Stability Mixed or Opened Vial
|
Final Concentration /Diluents |
STABILITY CRT/FRI |
Comments |
Ampicillin |
|
4 hrs (4°C) |
0.5-2g 100 ml NS 2.1–4g 250 ml NS |
24 hrs/72 hrs |
Do not freeze. Heat sensitive. Use immediately if D5W used as diluent(stable: only 4 hrs) , TR#138-139 |
Ampicillin / Sulbactam (Unasyn) |
|
4 hrs (4°C) |
1.5-3g 100ml NS |
32 hrs/72 hrs |
Do not freeze. Refrigerate immediately Use immediately if D5W used luent(stable: only 4 hrs), TR#149-150 |
Aprepitant(Emend) |
|
|
125mg in 125 ml NS |
24 hrs/NA |
PI |
Argatroban |
|
|
125 mg in 125 ml or 250 mg in 250 ml In NS or D5W |
48 hrs/96 hr |
Discard solution if cloudy or precipitate. Protect from sunlight. Reduce dose in liver disease. TR#166 |
Azithromycin (Zithromax) |
|
|
250-500mg/250 ml In D5W or NS |
24 hrs/7 days |
Do not exceed 2mg/ml TR#185 |
Aztreonam (Azactam) |
|
|
0.5-2g 100 m In NS or D5W |
48 hrs/7 days |
May develop slight pink tint on standing. Potency not affected. TR#188, USPL |
Bumetanide (Bumex) |
|
|
25mg in NS100 ml |
30 hrs/9 days |
USPM |
Caffeine citrate (Cafcit) |
|
|
150 mg/100 ml of D5W |
24 hrs/NA |
PI |
Calcium gluconate |
|
|
0-2g In 50 ml of NS or D5W 93meq/1.2L NS |
24 hrs/NA |
No stability information in refrigerator TR#238 |
Caspofungin (Cancidas) |
|
|
50 mg/250 ml NS only 70 mg/250 ml NS only |
24 hrs/48hrs |
Do not filter, Do not use Dextrose, LR can be use as alternative diluents(same stability), PI |
Cefazolin (Ancef / Kefzol) |
|
|
0.5-2 g 100 ml In D5W or NS |
48 hrs /14 days |
Stable 30 days in refrigerator after thawing. TR#265, USPL |
Cefepime (Maxipime) |
|
|
0.5-2 gm/100 ml In D5W or NS |
48 hrs/14 days |
Stable 7 days in refrigerator after thawing. TR#275-276, USPL |
Cefotaxime (Claforan) |
|
|
0.5-2g 100 ml In D5W or NS |
24 hrs/5 days |
Stable 10 days in refrigerator after thawing. TR#286 |
Cefoxitin (Mefoxin) |
|
|
1-2 g 100 ml In D5W or NS |
48 hrs/14 days |
Slight color change does not affect potency. USPL, TR#298-299 |
Ceftaroline (Teflaro) |
600mg/20 ml SW |
|
200-600mg in100 ml NS or D5W |
6 hrs/24 hrs |
PI |
Ceftazidime (Fortaz) |
|
|
0.5-2 g 100 ml In D5W or NS |
24 hrs/14 days |
CAUTION: Generates carbon dioxide upon reconstitution. Must vent during preparation. TR#306-307 |
Ceftriaxone (Rocephin) |
|
|
0.5-2 g 100 ml In D5W or NS |
48 hrs/14 days |
Light yellow / amber color okay. USPL,TR#319-320 |
Cefuroxime (Zinacef) |
|
|
0.75-1.5g 100 ml In D5W or NS |
48 hrs/14 days
|
Solution may darken, does not affect potency. TR#326-327, USPL |
Chlorothiazide(Diuril) |
500mg/20 ml SW |
|
500mg/20 ml or 250mg/10 ml In SW |
30 hrs/9 days |
Data in file, USPM |
Chlorpromazine(Thoazine) |
25mg/ml |
|
25-50 mg/50mlNS |
48 hrs/14 days |
USPL,TR#341 |
Ciprofloxacin |
|
|
200/400 mg premixed in 100/200 ml D5W |
2 days/14 days |
Maximum conc. = 2 mg/ml, NS can be use as diluents(same stability) Protect vial from light. USPL,TR#361-362, PI Stable after remove overwrap for 14 days/100 ml,30 days/200 ml |
Clindamycin (Cleocin) |
|
|
300-600mg in 100 ml In D5W or NS |
2 days/DNR |
Crystallization may occur upon refrigeration of vial. Crystals resolubilize upon warming to room temperature. TR#396-397, USPL |
Co-Trimoxazole (Sulfamethoxazole-Trimethoprim) (Bactrim / Septra) |
|
|
< 1.6mg/ml as TMP in D5W Do not use NS |
24 hrs/DNR |
Mix immediately prior to use if possible. Do NOT refrigerate. Do NOT use if cloudy or crystallized. Do not use glass bottle if conc > 0.8mg/ml as TMP, TR#1495-1497, CP |
Cyclosporine (Sandimmune IV) |
|
|
0.2-2.5 mg/ml In D5W/NS use VisIV/glass BT |
24 hrs/24 hrs |
Use of containers and tubing that does not contain DEHP Use 0.45-micron polyprolene filter TR#431 |
Daptomycin (Cubicin) |
250mg/5ml NS 500mg/10ml NS |
12 hrs (CRT) 48 hrs (4°C) |
0-1g/50 ml In NS or LR |
12 hrs/48 hrs |
No dextrose. Refrigerate un-opened vials PI |
Deferoxamine (Desferal) |
|
24 hrs(CRT) |
5-73mg/ml In NS(preferred) D5W(see comment) |
48 hrs/14 days |
Max Rate = 15mg/kg/hr (dry weight). OK to use D5W as diluents but no data for refrigerate. STABLE 48 HR in CRT CP,tr#450-451 |
Desmopressin (DDAVP) |
|
|
5-20 mcg in NS 50 ml |
use immediately |
Mix and use immediately. IV dose has 10 times diuretic effect of intranasal DDAVP |
Dexamethasone |
|
|
0-10 mg IVP 11-80 mg in 50 ml in NS |
48 hrs/14 days |
Protect from freezing and light. D5W can be use as altenative diluents but less stability data. TR#452,CP |
Dexmedetomidine (Precedex) |
|
|
Standard drip = 400 mcg in 100 ml NS (4 mcg/ml) |
48 hrs/14 days |
Mfg recommends NS as diluents but stable in D5W also per TR#468(stable for 48 hrs). Data in file, USPL |
Diltiazem (Cardiazem) |
|
|
Standard drip=100mg/100ml or 125mg/125ml in NS/ D5W |
48 hrs/14 days |
USPL, TR#490 |
Dobutamine |
|
|
Standard drip = 500 mg in D5W 250 ml (2mg/ml) Max conc.=5mg/ml |
48 hrs/ 14 days |
Premixed by Abbott stable 14 days after over wrap removed NS can be used as diluents(stability 24 hrs) TR#511,CP |
Dopamine
|
|
|
Standard drip = 800 mg in D5W 500 ml(1.6mg/ml) Max conc. = 3.2mg/ml |
48 hrs/ 7 days |
Premix by Abbott stable 7 days after over wrap removed NS can be used as diluents(stability 48 hrs) TR#531 |
Doripenem (Doribax) |
500 mg/10 ml In SW or NS |
1 hr |
0.5-1g 100 ml in NS |
12 hrs/72 hrs |
Stable 4/48 hrs In D5W TR#541 |
Doxycycline (Vibramycin) |
100 mg/10 ml in SW |
Discard unused portion |
100 mg/100 ml 200 mg/250 ml In D5W/NS |
48 hrs/7 days |
TR#567, USPL |
Epinephrine |
|
|
Standard drip = 2 mg in D5W 250 ml (8 mcg/ml) Max conc.= 32mcg/ml |
24 hrs/48 hrs |
NS can be used as diluent(stability 24 hrs), TR#592
|
Ertapenem (Invanz) |
1 gm/10 ml SW or NS |
Use immediately |
0-1g/ 50 ml NS not D5W |
6 hrs/24 hrs |
Use within 4 hr of removal from refrigeration. PI |
Erythromycin |
500 mg/10 ml SW 1 gm/20 ml SW |
14 days(4°C) 24hrs (CRT) |
0-500 mg/100 ml 501-1000 mg/250 ml NS IVPB not D5W |
24 hrs/14 days |
Reconstitute only with preservative-free water TR#605-607 |
Esmolol (Brevibloc) |
|
|
Standard drip = 2500 mg/ 250 ml NS (10 mg/ml) |
Mfr. Exp. Date |
Use within 24 hrs after open overwrap. No long term stability data per Mfg |
Esomeprazole (Nexium) |
40 mg/ 5ml NS |
12 hrs (CRT) |
Standard drip = 40 mg/50 ml NS or D5W (0.8 mg/ml) |
48 hrs/120 hrs |
Mfg informs 12 hrs stability per PI but stable over 48/120 hrs per TR#616 |
Fenoldopam (Corlopam) |
|
|
Standard drip = 10 mg/250 ml NS or D5W (40mcg/ml) Max conc. 160 mg/ml |
48 hrs/72 hrs |
Dosing range: 0.1-1.6 mcg/kg/hr, protected from light TR#662, USPL
|
Fentanyl |
|
|
Standard drip = 2500 mcg/ 250 ml in NS(10 mcg/ml) |
48 hrs/14 days |
D5W can be used as diluents but less stability data CP, TR #670, USPL |
Ferric gluconate complex (Ferrlect) |
|
|
125-250 MG/100 ml NS |
USE IMMEDIATELY |
PI DO NOT USE DEXTROSE |
Fluconazole (Diflucan) |
|
|
2mg/ml in NS(pre-mixed) |
48 hrs/14 days |
USPL Premixed by Hospira stable 30 days after over wrap removed |
Folic acid |
|
|
0-5mg/50 ml D5W/NS |
USE IMMEDIATELY |
NO DATA |
Fosphenytoin (Cerebryx) |
|
Stable for 48hrs in CRT |
500-1000 mgPE/50 ml In NS or D5W |
48 hrs/14 days |
TR#724, USPL |
Furosemide |
|
|
100 mg/100 ml In NS |
30 hrs/ 9 days |
Keep from light, refrigeration may cause precipitin which dose not influence effect. D5W can be used as diluents(24 hrs), TR#727, USPM |
Ganciclovir |
500 mg/10 ml SWPF |
12 hrs in (CRT) DNR* |
Max conc. 10mg/ml In D5W or NS |
48 hrs/14 days |
*Possibility of precipitation TR#742-743 |
Gentamicin (Garamycin) |
|
|
All doses in 100 ml In NS or D5W |
48 hrs/14 days |
TR#756, USPL Premixed by Hopira stable 30 days after over wrap removed |
Glucagon |
1mg/1 ml of SW |
|
10 mg/100ml in D5W |
Use immediately |
USE IMMEDIATELY(Mfg dose not recommended IV infusion: no stability data) IM# 684 |
Heparin
|
|
|
50-100 units/ml In D5W or NS |
48 hrs/14 days |
USPL |
Hydrocortisone (Solu-Cortef) |
|
3 days(CRT)* |
<500 mg IVP over 1 min 500-3000 mg in 50ml NS/D5W |
4 hrs |
2-60 mg/ml conc. Is stable only for 4 hrs, *need light protection, PI |
Hydromorphone |
|
|
1mg/ml or 10 mg/ml In NS//D5W |
30 hrs/9 days |
TR#852-853, CP, USPM |
Insulin(regular) |
|
|
250 units/250 ml of NS |
48 hrs/7 days |
ASHP Midyear Clinical Meeting 2010. 2010 ;p 172. HOSP pharm 2012;47(5)367-370, USPM |
Iron Sucrose (Venofer) |
|
|
1-2 mg/ml in NS
|
48 hrs/ 7 hrs |
Do Not Mix in D5W, PI |
Iron Dextran (InFeD/Dexferrum) |
|
|
Total dose infusion in NS 250-500 ml (unlabeled use) Daily dose in NS 100 ml |
Use immediately |
Dextrose results in a greater incidence of pain and phlebitis Mfr does not have any stability dataà use immediately |
Isoproterenol(Isuprel) |
1mg/5ml |
|
Standard drip 1mg/250 ml in D5W (Max conc : 5mg/250ml) |
48 hrs/10 days |
NS can be used as diluents(24 hrs) Need to protect from light TR#919, USPL |
Labetalol (Normodyne/Trandate) |
|
|
Standard drip = 200 mg/160 ml (1 mg/ml) In D5W Max conc. 3.75 mg/ml |
48 hrs/72 hrs |
NS can be alternative diluent but stable only 24hrs/24hrs To make max conc.:375mg(75 ml)+25 ml of D5WÃ 100ml(final volume) TR#934, USPL, CP |
Lacosamide(Vimpat) |
|
|
0-400mg in NS/D5W 50 ml |
24 hrs/NA |
PI |
Leucovorin |
10-20mg/ml in SW |
see comment* |
0-1.5mg/ml in NS or D5W |
30 hrs/4 days |
*Use immediately if mixed in preservative free water but bacteriostatic water is stable for 7 days in CRT. TR#939-940, USPM |
Levofloxacin (Levaquin)
|
|
|
250mg/50 ml 500mg/100 ml 750 mg/150ml |
48 hrs/6* or 14** days |
Premixed stable 7 days(500 or 750 mg), 6 days(250 mg) after over wrap removed, TR#944-946, CP,USPL(*w/o light protection,**need light protection) |
Lepirudin (Refludan) |
50 mg/2 ml SW |
24 Hrs |
100mg/250 ml in NS or D5W |
24 hrs/NA |
PI |
Levetiracetam (Keppra) |
|
|
0.5-1.5g In 100ml NS or D5W |
24 hrs/24 hrs |
PI |
Lorazepam(Ativan)
|
|
|
50mg in D5W in 250ml (Conc 200mg/ml) |
24 hrs/DNR |
Use VISIV bag or glass container |
Magnesium sulfate |
|
|
Recommended Conc.<3.7g/100ml in NS or D5W |
48 hrs/14 days |
Max infusion rate is 150 mg/min. TR#979, USPL Premixed by Hospira stable 30 days after over wrap removed
|
Meropenem (Merrem) |
1gm/20ml SW 500mg/10ml SW |
12 hrs(4°C) 2 hrs (CRT) |
0.5-1 g in 100ml NS IVPB |
4 hrs/24 hrs |
Stable only 1 hr/6hrs in D5W PI |
Methocarbamol
|
|
|
<1000mg/100 ml 1001-3000 mg/250 ml in D5W or NS(Max conc:15mg/ml) |
48 hrs/DNR |
Do not refrigerate after dilution. May also be administered undiluted IF dose < 500 mg . TR1023, USPL |
Methylprednisolone (Solu-Medrol) |
|
|
251-1000mg in 50 ml over 1000 mg in 100 ml In NS |
48 hrs /48 hrs |
0-250 mg IV push, over 250mg IVPB D5W can be alternative diluents but less stable(8 hrs in CRT) TR#1041 |
Methyldopate |
|
|
250-500 mg in 50 ml 501-1000 mg in 100 ml D5W or NS |
24 hrs/24 hrs |
Administer over 30-60 minutes TR#1037 |
Metoclopramide (Reglan) |
|
|
11-20 mg in 50ml In D5W or NS |
24 hrs/24 hrs |
Tr#1050-1051 |
Metronidazole (Flagyl) |
|
|
250 mg/50 ml 500mg/100 ml in NS (Conc:5mg/ml) |
48 hrs/DNR |
Refrigeration may result in crystal formation but may re-dissolve on warming to CRT. USPL Premixed by Hospira stable 30 days after over wrap removed |
Micafungin (Mycamine) |
|
24 hrs(CRT) |
50-150 mg/100ml In NS or D5W |
24 hrs/24 hrs |
Protect from light(stable only for 12 hrs under light). Flush line with saline pre-dose. DO NOT SHAKE(Gently swirl to dissolve) PI, data in file |
Milrinone (Primacor) |
|
|
Standard drip = 20 mg in 100 ml D5W(0.2mg/ml) Max conc. 0.4mg/ml |
48 hrs/14 days |
NS can be alternative diluent(same stability) Stable 30 days after removed from overwrap. TR#1086-1087, USPL |
Morphine |
|
|
Standard drip = 100 mg in 100 ml NS/D5W |
30 hrs/9 days |
TR#1103-1105, CP, USPM
|
Multivitamins (M.V.I Adult) |
Mix contents of Vial 1 and Vial 2 |
24 hrs (4°C) |
Dilute in at least 500ml, preferably in 1L NS, D5W |
24 hrs/24 hrs |
Store in refrigerator, protect from light, PI |
Mycophenolate (Cellcept) |
500 mg vial |
|
Final concentration: 6 mg/ml in D5W |
30 hrs/7 days
|
Infuse over at least 2 hours –Never administer by rapid or bolus IV inj. Incompatible with other solutions (only D5W), TR#1127, USPM, (6 hrs per Mfg) |
Nafcillin Sodium |
|
|
2g/100 ml or 10-12g /500 ml In NS or D5w |
30 hrs/9 days |
TR#1130-1131, CP, USPM |
Naloxone (Narcan) |
|
|
1mg/250 ml of NS |
24 hrs/24 hrs |
TR#1140-1141 |
Nesiritide (Natrecor) |
1.5 mg/5 ml D5W |
Do not shake |
Standard drip = 1.5 mg in 250 ml D5W (6 mcg/ml) |
24 hrs/24 hrs |
Bolus dose can be withdrawn from infusion Do Not Mix in NS, PI |
Nicardipine (Cardene) |
|
|
0.1mg/ml, 0.2mg/ml in D5W(pre-mixed) Max conc. = 0.5mg/ml |
48 hrs/ 7 days |
Also compatible w/ NS, (Protect from light), TR#1145-1147, USPL, CP(max conc is central line only) Premixed stable 7 days after open cardboard carton |
Nitroglycerin |
|
|
100-400 mcg/ml in D5W or NS |
48 hrs/14 days |
Do not use PVC container, TR#1156-1157, USPL |
Nitroprusside (Nipride) |
|
|
0.2-0.4mg/ml in D5W or NS |
48 hrs/NA |
Protect from light. Dilute with preservative free SWFI, D5W, NS Mfg does not recommended NS as diluents but NS still can be alternative diluents, 0.8mg/ml is stable for 24 hrs only. .TR#1405-1405, USPL |
Norepinephrine (Levophed) |
|
|
Standard drip = 4mg in 500 ml D5W/NS Max conc. 64 mcg/ml |
30 hrs/ 9 days |
CP, PR1163-1164, USPM
|
Octreotide (Sandostatin) |
|
14 days in CRT |
500 mcg/250 ml in NS(2 mcg/ml) Max conc 5 mcg/ml |
48 hrs/NA
|
D5W is stable for 24 hrs CP, TR#1169-1170 |
Ondansetron (Zofran) |
|
|
9-16 mg/50 ml in NS or D5W |
48 hrs/14 days |
*USPL,TR#1173-1175 Premixed by Hospira stable 30 days after over wrap removed |
Pamidronate |
30 mg /10 ml SW 90 mg /10 ml SW |
24 hr (4°C) |
30-90 mg dose in 250-1000 ml D5W |
48 hrs/14 days |
Do not mix with calcium containing solutions, including D5LR or LR NS can be use diluents but stable only 24 hrs. CP, USPL |
Pantoprazole (Protonix) |
|
|
40-80 mg in NS or D5W 100 ml |
30 hrs/9 days |
Does not require filtration. CP,USPM |
Penicillin G (Potassium) (Sodium) |
5 MU/ 8.2 ml SW 20 MU/ 33 ml SW (0.5 MU/ML) |
7 days (4°C)
|
0-2 MU/50 ML 2.1-4 MU/100 ML 4.1-10 MU/250 ML IN NS or D5W |
24 hrs/ 7 days
|
(1.7mEq K+/ MU Potassium) (2 mEq Na+/MU Sodium) CP, see attached file |
Phenylephrine (Neo-synephrine) |
|
|
Standard drip = 10 mg in 250 ml NS/D5W(40 mcg/ml) Conc. range 40-200 mcg/ml |
48 hrs/48 hrs |
TR#1259-1260, USPL |
Phenytoin (Dilantin) |
|
|
101-1000mg/ml in 50 mlNS |
2 hrs/NA |
Mix immediately prior to use. Administer with 0.22 micron filter. Do not use Dextrose, Do not refrigerate. TR#1264 |
Phytonadione(Vit K) (Aqua-Mephyton) |
|
|
1-20 mg/50ml in D5W or NS |
24 hrs/24 hrs |
Protect from light. CP |
Potassium chloride |
|
|
1-40 meq/100-1000 ml in D5W or NS |
48 hrs/14 days |
Premixed by Hospira stable 30 days after over wrap removed USPL |
Potassium phospate |
|
|
1-20 mM/250 ml 21-40 mM/500 ml in NS or D5W |
24 hrs/24 hrs |
Do not use with LR CP |
Pipercillin / Tazobactam (Zosyn) |
2.25gm/10ml SW 3.375 m/l15 ml SW 4.5 gm/20ml SW |
24 hrs(CRT) 48 hrs(4°C) |
2.25-4.5g In 100ml NS or D5W |
48 hrs/14 days |
Stable 14 days in refrigerator after thawing. CP,USPL |
Prochlorperazine (compazine) |
|
|
11-40mg in NS or D5W (50-1000 ml) |
24 hrs/24 hrs |
Protect from light. May give IV slow push if less than 10 mg TR#1317-1318 |
Quinupristin/Dalfo-pristin (Synercid) |
500 mg/ 5ml in SW or D5W |
30 min refrig. |
250ml D5W IVPB desired conc. : 2mg/ml |
5 hrs/54 hrs |
Incompatible with NS. Send each dose with D5W 50 ml flush bag. PI |
Rifampin (Rifadin) |
600mg/10ml SWFI |
24hrs (CRT) |
0-600mg in 500 ml 0-600 mg in 100 ml |
4 hrs/NA in D5W 24 hrs/NA in NS |
Protect from light/heat 100 ml infuse over 30 min or 500 ml infuse over 3 hrs per PI |
Rocronium (Zemuron) |
|
60 days(CRT) |
Standard drip : 250mg in 250 ml In NS/D5W(1 mg/ml) Conc. range 1-5 mg/ml |
24 hrs/NA |
LD 0.6-1.2mg/kg MD 8-12mcg/kg/mins PI, TR#1375 |
Sodium Bicarbonate |
|
|
1) 50-200 meq/1L 2) 182 meq/ 1182ml (conc:154 meq/ml) IN Sterile water/D5W (standard infusion) |
30 hrs/9 days |
NS is stable for 24 hrs Data in file, USPM |
Thiamine |
|
|
100mg/50ml In D5W or NS |
24 hrs/24 hrs |
Tr#1448-1449 |
Tigecycline (Tygacil) |
5.3 ml of NS or D5W |
6 hrs(CRT) |
50-100mg in 100ML NS or D5W |
24 hrs/48 hrs |
Max Conc.= 1 mg/ml TR#1470, PI |
Tobramycin
|
|
4 days(4°C) 24 hours(CRT) |
All doses in 100 ml NS or D5W |
48 hrs/14 days |
TR#1476-1477, USPL Premixed by Hospira stable 30 days after over wrap removed |
Valproate Sodium (Depacon) |
|
|
0-1g in 50 ml D5W or NS |
2 days/NA |
Maximum infusion rate = 20 mg/min TR#1503-1504, USPL |
Vancomycin (Vancocin) |
1 gm/20 ml SW
|
9 days (4°C) |
<5 mg/ml D5W/NS IVPB |
30 hrs/9 days |
Compounded oral vancomycin liquid is stable for 75 days in FRI USPM,TR#1550, date in file |
Vasopressin (Pitressin) |
|
|
Standard drip = 100 units in D5W or NS (1units/ml) |
Use immediately |
Stability data is not available IM#1368 |
Vecuronium (Norcuron) |
10mg/10ml SW |
24hrs SW(4°C) |
Standard drip : 50mg/500ml in D5W/NS (Conc. 1 mg/ml) |
24 hrs/ 24 hrs |
Compatible with D5W, NS,LR PI, TR#1524 |
Voriconazole (VFEND I.V.) |
200 mg/19 ml SW |
24 hr (4°C) |
Further dilution in D5W or NS to 0.5 -5 mg/ml is required |
30 hr/ 9 days |
Vial contains vacuum to ease reconstitution process. CP, USPM |
Zoledronic Acid (Zometa) |
|
24 hr (4°C) |
Reconstitute w/ 5ml SW. Further dilute in D5W/NS 100 ml for infusion |
NA/24 hrs |
Do not mix with calcium containing solutions such as D5LR or LR. PI |