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Clinical Tools - IV Stability Guideline

IV Product Preparation

Dilution and Stability Guidelines

Memorial Hospital Pharmacy Department

 

                

                        Agent

 

Size/Diluents

 

Stability

Mixed or Opened Vial

 

 

Final Concentration

/Diluents

                

Stability CRT/FRG

 

Comments

Acetylcysteine I.V. (Mucomyst)

6 g/30 ml SW

 

See Comments

24 hrs/NA

LD: 150mg/kg in 200 ml IV over 1 hr

2nd Dose: 50mg/kg in 500 ml IV over 4 hrs. 3rd Dose: 100mg/kg in 1000 ml IV over 16 hrs. Neb solution is stable for 96 hrs in FRI. PI

Acyclovir

(Zovirax)

500 mg/10 ml SW

1000 mg/20 ml SW

12hrs

< 500 mg in 100 ml

> 500 mg in 250 ml

In D5W or NS

48 hrs/DNR

May cause precipitation if refrigerated; product will re-solubilize at room temperature without loss of potency.

Recommended conc. <7mg/ml. *TR#8-9, USPL

Allopurinol

(Aloprim)

500 mg/25 ml SW

10 hrs (CRT)

≤ 6 mg/ml

in D5W or NS

10 hrs/DNR

Do not refrigerate. Swirl, don’t shake.

TR#21

Alteplase(TPA)

50 mg/50 ml SW

100mg/100 ml SW

2mg/2 ml SW

 

8 hrs(CRT)

1mg/ml in syringe

5-10mg in 500 ml in NS

24 hrs/24 hrs

Frozen syringe is stable for 45 days

TR#28-29, USP

Amikacin

(Amikin)

 

 

<500 mg in 100ml

>500 mg in 250ml

In NS or D5W

48 hrs/14 days

Discoloration may occur due to oxidation without loss of potency

TR#37-38, USPL

 

Aminocaproic Acid

(Amicar)

 

 

1 g per 50ml

In NS or D5W

48 hrs/7 days

More than 30gms over a 24 hrs period not advised. Yellow discoloration occurs after 24 hrs at 23°C without loss of potency.

Acceptable conc. range s 10-45 mg/ml . * TR 91, USPL

Aminophylline

(Theophylline)

 

 

0-250mg /50 ml

251-500 mg/ 100ml

in D5W/NS

1mg/ml D5W500 ml(PRE-MIX)

48hrs/DNR

TR#93-94, Do not refrigerate(risk of crystallization)

 

Amiodarone

(Cordarone)

 

 

Loading dose = 150 mg in 100 ml D5W

2 hrs/DNR

Discard bolus if not used (stable 2hrs). Retain opened vial in carton until contents used.

Standard Infusion =

500 mg in 500 ml D5W

Max 6 mg/ml

24 hrs/DNR

Prepare drip in glass bottle or VisIV. Do not use evacuated glass. Conc>2 mg/ml need central line. Use in-line filter.

NS can be use but only for 1.8 or 2 mg/ml (Amiodarone precipitation in NS due to salting out has been reported at a lower amiodarone hydrochloride concentration.). TR#104-105,CP

Amphotericin B

(Fungizone)

50 mg/10 ml SW(use preservative free)

7 days (4°C)

24 hrs (CRT) if protected from light

<0.1mg/ml(peripheral)

<0.25mg/ml(central and

fluid restriction)*

In D5W

24 hrs/24 hrs

Protect from light. Do Not Mix in NS

*Uptodate

Use in-line filter(minimum 1 micron), IM#106-107,

Amphotericin B Lipid Complex (Abelcet)

 

 

Final con. 1-2mg/ml

Diluents D5W

6 hrs/48 hrs

Intact vials protect from light, keep refrigerate.

Use 5-micron filter needle. PI

 

 

                

Agent

 

Size/Diluents

 

Stability

Mixed or Opened Vial

 

 

Final Concentration

/Diluents

                

STABILITY CRT/FRI

                

 

Comments

Ampicillin

 

 

4 hrs (4°C)

0.5-2g 100 ml NS

2.1–4g 250 ml NS

24 hrs/72 hrs

Do not freeze. Heat sensitive.

Use immediately if D5W used as diluent(stable: only 4 hrs) ,

TR#138-139

Ampicillin / Sulbactam

(Unasyn)

 

4 hrs (4°C)

1.5-3g 100ml NS

32 hrs/72 hrs

Do not freeze. Refrigerate immediately

Use immediately if D5W used luent(stable: only 4 hrs), TR#149-150

Aprepitant(Emend)

 

 

125mg in 125 ml NS

24 hrs/NA

PI

Argatroban

 

 

125 mg in 125 ml

or 250 mg in 250 ml

In NS or D5W

48 hrs/96 hr

Discard solution if cloudy or precipitate.

Protect from sunlight.

Reduce dose in liver disease. TR#166

Azithromycin

(Zithromax)

 

 

250-500mg/250 ml

In D5W or NS

24 hrs/7 days

Do not exceed 2mg/ml

TR#185

Aztreonam

(Azactam)

 

 

0.5-2g 100 m

In NS or D5W

48 hrs/7 days

May develop slight pink tint on standing. Potency not affected.

TR#188, USPL

Bumetanide

(Bumex)

 

 

25mg in NS100 ml

30 hrs/9 days

USPM

Caffeine citrate

(Cafcit)

 

 

150 mg/100 ml of D5W

24 hrs/NA

PI

Calcium gluconate

 

 

0-2g In 50 ml of NS or D5W

93meq/1.2L NS

24 hrs/NA

No stability information in refrigerator

TR#238

Caspofungin

(Cancidas)

 

 

50 mg/250 ml NS only

70 mg/250 ml NS only

24 hrs/48hrs

Do not filter, Do not use Dextrose, LR can be use as alternative diluents(same stability), PI

Cefazolin

(Ancef / Kefzol)

 

 

0.5-2 g 100 ml

In D5W or NS

48 hrs /14 days

Stable 30 days in refrigerator after thawing.

TR#265, USPL

Cefepime

(Maxipime)

 

 

0.5-2 gm/100 ml

In D5W or NS

48 hrs/14 days

Stable 7 days in refrigerator after thawing.

TR#275-276, USPL

Cefotaxime

(Claforan)

 

 

0.5-2g 100 ml

In D5W or NS

24 hrs/5 days

Stable 10 days in refrigerator after thawing.

TR#286

Cefoxitin (Mefoxin)

 

 

1-2 g 100 ml

In D5W or NS

48 hrs/14 days

Slight color change does not affect potency.

USPL, TR#298-299

Ceftaroline

(Teflaro)

600mg/20 ml SW

 

200-600mg in100 ml

NS or D5W

6 hrs/24 hrs

PI

Ceftazidime

(Fortaz)

 

 

0.5-2 g 100 ml

In D5W or NS

24 hrs/14 days

CAUTION: Generates carbon dioxide upon reconstitution. Must vent during preparation. TR#306-307

Ceftriaxone

(Rocephin)

 

 

0.5-2 g 100 ml

In D5W or NS

48 hrs/14 days

Light yellow / amber color okay. USPL,TR#319-320

Cefuroxime

(Zinacef)

 

 

0.75-1.5g 100 ml

In D5W or NS

48 hrs/14 days

 

Solution may darken, does not affect potency. TR#326-327, USPL

Chlorothiazide(Diuril)

500mg/20 ml SW

 

500mg/20 ml or 250mg/10 ml

In SW

30 hrs/9 days

Data in file, USPM

Chlorpromazine(Thoazine)

25mg/ml

 

25-50 mg/50mlNS

48 hrs/14 days

USPL,TR#341

Ciprofloxacin

 

 

200/400 mg premixed

in 100/200 ml D5W

2 days/14 days

Maximum conc. = 2 mg/ml, NS can be use as diluents(same stability)

Protect vial from light. USPL,TR#361-362, PI

Stable after remove overwrap for 14 days/100 ml,30 days/200 ml

Clindamycin

(Cleocin)

 

 

300-600mg in 100 ml

In D5W or NS

2 days/DNR

Crystallization may occur upon refrigeration of vial. Crystals resolubilize upon warming to room temperature. TR#396-397, USPL

Co-Trimoxazole

(Sulfamethoxazole-Trimethoprim)

(Bactrim / Septra)

 

 

 

< 1.6mg/ml as TMP

in D5W

Do not use NS

24 hrs/DNR

Mix immediately prior to use if possible.

Do NOT refrigerate. Do NOT use if cloudy or crystallized.

Do not use glass bottle if conc > 0.8mg/ml as TMP, TR#1495-1497, CP

Cyclosporine

(Sandimmune IV)

 

 

0.2-2.5 mg/ml

In D5W/NS

use VisIV/glass BT

24 hrs/24 hrs

Use of containers and tubing that does not contain DEHP

Use 0.45-micron polyprolene filter

TR#431

Daptomycin

(Cubicin)

250mg/5ml NS

500mg/10ml NS

12 hrs (CRT)

48 hrs (4°C)

0-1g/50 ml

In NS or LR

12 hrs/48 hrs

No dextrose. Refrigerate un-opened vials

PI

Deferoxamine

(Desferal)

 

 

 

24 hrs(CRT)

5-73mg/ml

In NS(preferred)

D5W(see comment)

 

48 hrs/14 days

Max Rate = 15mg/kg/hr (dry weight). OK to use D5W as diluents but no data for refrigerate. STABLE 48 HR in CRT

CP,tr#450-451

Desmopressin

(DDAVP)

 

 

5-20 mcg in NS 50 ml

use immediately

Mix and use immediately.

IV dose has 10 times diuretic effect of intranasal DDAVP

Dexamethasone

 

 

0-10 mg IVP

11-80 mg in 50 ml in NS

48 hrs/14 days

Protect from freezing and light.

D5W can be use as altenative diluents but less stability data. TR#452,CP

Dexmedetomidine

(Precedex)

 

 

Standard drip = 400 mcg in 100 ml NS (4 mcg/ml)

48 hrs/14 days

Mfg recommends NS as diluents but stable in D5W also per TR#468(stable for 48 hrs). Data in file, USPL

Diltiazem

(Cardiazem)

 

 

Standard drip=100mg/100ml or 125mg/125ml in NS/ D5W

48 hrs/14 days

USPL, TR#490

Dobutamine

 

 

Standard drip = 500 mg

in D5W 250 ml (2mg/ml)

Max conc.=5mg/ml

48 hrs/ 14 days

Premixed by Abbott stable 14 days after over wrap removed

NS can be used as diluents(stability 24 hrs)

TR#511,CP

Dopamine

 

 

 

Standard drip = 800 mg

in D5W 500 ml(1.6mg/ml)

Max conc. = 3.2mg/ml

48 hrs/ 7 days

Premix by Abbott stable 7 days after over wrap removed

NS can be used as diluents(stability 48 hrs)

TR#531

Doripenem

(Doribax)

500 mg/10 ml

In SW or NS

1 hr

0.5-1g 100 ml in NS

12 hrs/72 hrs

Stable 4/48 hrs In D5W

TR#541

Doxycycline

(Vibramycin)

100 mg/10 ml in SW

Discard unused portion

100 mg/100 ml

200 mg/250 ml

In D5W/NS

48 hrs/7 days

TR#567, USPL

Epinephrine

 

 

Standard drip = 2 mg

in D5W 250 ml (8 mcg/ml)

Max conc.= 32mcg/ml

24 hrs/48 hrs

NS can be used as diluent(stability 24 hrs), TR#592

 

Ertapenem

(Invanz)

1 gm/10 ml SW or NS

Use immediately

0-1g/ 50 ml NS

not D5W

6 hrs/24 hrs

Use within 4 hr of removal from refrigeration. PI

Erythromycin

 

500 mg/10 ml SW

1 gm/20 ml SW

14 days(4°C)

24hrs (CRT)

0-500 mg/100 ml

501-1000 mg/250 ml

NS IVPB not D5W

24 hrs/14 days

Reconstitute only with preservative-free water

TR#605-607

Esmolol

(Brevibloc)

 

 

Standard drip = 2500 mg/ 250 ml NS (10 mg/ml)

Mfr. Exp. Date

Use within 24 hrs after open overwrap.

No long term stability data per Mfg

Esomeprazole

(Nexium)

40 mg/ 5ml NS

12 hrs (CRT)

Standard drip = 40 mg/50 ml NS or D5W (0.8 mg/ml)

48 hrs/120 hrs

Mfg informs 12 hrs stability per PI but stable over 48/120 hrs per TR#616

Fenoldopam

(Corlopam)

 

 

Standard drip = 10 mg/250 ml NS or D5W (40mcg/ml)

Max conc. 160 mg/ml

48 hrs/72 hrs

Dosing range: 0.1-1.6 mcg/kg/hr, protected from light

TR#662, USPL

 

Fentanyl

 

 

Standard drip = 2500 mcg/ 250 ml in NS(10 mcg/ml)

48 hrs/14 days

D5W can be used as diluents but less stability data

CP, TR #670, USPL

Ferric gluconate complex

(Ferrlect)

 

 

125-250 MG/100 ml NS

USE IMMEDIATELY

PI

DO NOT USE DEXTROSE

Fluconazole

(Diflucan)

 

 

2mg/ml in NS(pre-mixed)

48 hrs/14 days

USPL

Premixed by Hospira stable 30 days after over wrap removed

Folic acid

 

 

0-5mg/50 ml D5W/NS

USE IMMEDIATELY

NO DATA

Fosphenytoin

(Cerebryx)

 

Stable for 48hrs in CRT

500-1000 mgPE/50 ml

In NS or D5W

48 hrs/14 days

TR#724, USPL

Furosemide

 

 

100 mg/100 ml

In NS

30 hrs/ 9 days

Keep from light, refrigeration may cause precipitin which dose not influence effect. D5W can be used as diluents(24 hrs),

TR#727, USPM

Ganciclovir

500 mg/10 ml SWPF

12 hrs in (CRT)

DNR*

Max conc. 10mg/ml

In D5W or NS

48 hrs/14 days

*Possibility of precipitation

TR#742-743

Gentamicin

(Garamycin)

 

 

All doses in 100 ml

In NS or D5W

48 hrs/14 days

TR#756, USPL

Premixed by Hopira stable 30 days after over wrap removed

Glucagon

1mg/1 ml of SW

 

10 mg/100ml in D5W

Use immediately

USE IMMEDIATELY(Mfg dose not recommended IV infusion: no stability data)

IM# 684

Heparin

 

 

 

50-100 units/ml

In D5W or NS

48 hrs/14 days

USPL

Hydrocortisone

(Solu-Cortef)

 

3 days(CRT)*

<500 mg IVP over 1 min

500-3000 mg in 50ml NS/D5W

4 hrs

2-60 mg/ml conc. Is stable only for 4 hrs,

*need light protection, PI

Hydromorphone

 

 

1mg/ml or 10 mg/ml

In NS//D5W

30 hrs/9 days

TR#852-853, CP, USPM

Insulin(regular)

 

 

250 units/250 ml of NS

48 hrs/7 days

ASHP Midyear Clinical Meeting 2010. 2010 ;p 172.

HOSP pharm 2012;47(5)367-370, USPM

Iron Sucrose

(Venofer)

 

 

1-2 mg/ml in NS

 

48 hrs/ 7 hrs

Do Not Mix in D5W, PI

Iron Dextran

(InFeD/Dexferrum)

 

 

Total dose infusion in NS 250-500 ml (unlabeled use)

Daily dose in NS 100 ml

Use immediately

Dextrose results in a greater incidence of pain and phlebitis

Mfr does not have any stability dataà use immediately

Isoproterenol(Isuprel)

1mg/5ml

 

Standard drip 1mg/250 ml

in D5W

(Max conc : 5mg/250ml)

48 hrs/10 days

NS can be used as diluents(24 hrs)

Need to protect from light

TR#919, USPL

Labetalol (Normodyne/Trandate)

 

 

Standard drip = 200 mg/160 ml

(1 mg/ml) In D5W

Max conc. 3.75 mg/ml

48 hrs/72 hrs

NS can be alternative diluent but stable only 24hrs/24hrs

To make max conc.:375mg(75 ml)+25 ml of D5Wà100ml(final volume) TR#934, USPL, CP

Lacosamide(Vimpat)

 

 

0-400mg in NS/D5W 50 ml

24 hrs/NA

PI

Leucovorin

10-20mg/ml in SW

see comment*

0-1.5mg/ml in NS or D5W

30 hrs/4 days

*Use immediately if mixed in preservative free water but bacteriostatic water is stable for 7 days in CRT. TR#939-940, USPM

Levofloxacin

(Levaquin)

 

 

 

250mg/50 ml

500mg/100 ml

750 mg/150ml

48 hrs/6* or 14** days

Premixed stable 7 days(500 or 750 mg), 6 days(250 mg) after over wrap removed, TR#944-946, CP,USPL(*w/o light protection,**need light protection)

Lepirudin

(Refludan)

50 mg/2 ml SW

24 Hrs

100mg/250 ml

in NS or D5W

24 hrs/NA

PI

Levetiracetam

(Keppra)

 

 

0.5-1.5g

In 100ml NS or D5W

24 hrs/24 hrs

PI

Lorazepam(Ativan)

 

 

 

50mg in D5W in 250ml

(Conc 200mg/ml)

24 hrs/DNR

Use VISIV bag or glass container

Magnesium sulfate

 

 

Recommended Conc.<3.7g/100ml

in NS or D5W

48 hrs/14 days

Max infusion rate is 150 mg/min. TR#979, USPL

Premixed by Hospira stable 30 days after over wrap removed

 

Meropenem

(Merrem)

1gm/20ml SW

500mg/10ml SW

12 hrs(4°C)

2 hrs (CRT)

0.5-1 g

in 100ml NS IVPB

4 hrs/24 hrs

Stable only 1 hr/6hrs in D5W

PI

Methocarbamol

 

 

 

<1000mg/100 ml

1001-3000 mg/250 ml

in D5W or NS(Max conc:15mg/ml)

48 hrs/DNR

Do not refrigerate after dilution. May also be administered undiluted IF dose < 500 mg .

TR1023, USPL

Methylprednisolone

(Solu-Medrol)

 

 

251-1000mg in 50 ml

over 1000 mg in 100 ml

In NS

48 hrs /48 hrs

0-250 mg IV push, over 250mg IVPB

D5W can be alternative diluents but less stable(8 hrs in CRT)

TR#1041

Methyldopate

 

 

250-500 mg in 50 ml

501-1000 mg in 100 ml

D5W or NS

24 hrs/24 hrs

Administer over 30-60 minutes

TR#1037

Metoclopramide

(Reglan)

 

 

11-20 mg in 50ml

In D5W or NS

24 hrs/24 hrs

Tr#1050-1051

Metronidazole

(Flagyl)

 

 

250 mg/50 ml

500mg/100 ml in NS

(Conc:5mg/ml)

48 hrs/DNR

Refrigeration may result in crystal formation but may re-dissolve on warming to CRT. USPL

Premixed by Hospira stable 30 days after over wrap removed

Micafungin

(Mycamine)

 

24 hrs(CRT)

50-150 mg/100ml

In NS or D5W

24 hrs/24 hrs

Protect from light(stable only for 12 hrs under light). Flush line with saline pre-dose. DO NOT SHAKE(Gently swirl to dissolve)

PI, data in file

Milrinone

(Primacor)

 

 

Standard drip = 20 mg in 100 ml D5W(0.2mg/ml)

Max conc. 0.4mg/ml

48 hrs/14 days

NS can be alternative diluent(same stability)

Stable 30 days after removed from overwrap.

TR#1086-1087, USPL

Morphine

 

 

Standard drip = 100 mg in 100 ml NS/D5W

30 hrs/9 days

TR#1103-1105, CP, USPM

 

Multivitamins

(M.V.I Adult)

Mix contents of Vial 1 and Vial 2

24 hrs (4°C)

Dilute in at least 500ml, preferably in 1L NS, D5W

24 hrs/24 hrs

Store in refrigerator, protect from light, PI

Mycophenolate

(Cellcept)

500 mg vial

 

Final concentration:

6 mg/ml in D5W

30 hrs/7 days

 

Infuse over at least 2 hours –Never administer by rapid or bolus IV inj. Incompatible with other solutions (only D5W),

TR#1127, USPM, (6 hrs per Mfg)

Nafcillin Sodium

 

 

2g/100 ml or

10-12g /500 ml

In NS or D5w

30 hrs/9 days

TR#1130-1131, CP, USPM

Naloxone

(Narcan)

 

 

1mg/250 ml of NS

24 hrs/24 hrs

TR#1140-1141

Nesiritide

(Natrecor)

1.5 mg/5 ml D5W

Do not shake

Standard drip = 1.5 mg in 250 ml D5W (6 mcg/ml)

24 hrs/24 hrs

Bolus dose can be withdrawn from infusion

Do Not Mix in NS, PI

Nicardipine

(Cardene)

 

 

0.1mg/ml, 0.2mg/ml in D5W(pre-mixed)

Max conc. = 0.5mg/ml

48 hrs/ 7 days

Also compatible w/ NS, (Protect from light),

TR#1145-1147, USPL, CP(max conc is central line only)

Premixed stable 7 days after open cardboard carton

Nitroglycerin

 

 

100-400 mcg/ml

in D5W or NS

48 hrs/14 days

Do not use PVC container, TR#1156-1157, USPL

Nitroprusside

(Nipride)

 

 

0.2-0.4mg/ml

in D5W or NS

48 hrs/NA

Protect from light. Dilute with preservative free SWFI, D5W, NS

Mfg does not recommended NS as diluents but NS still can be alternative diluents, 0.8mg/ml is stable for 24 hrs only.

.TR#1405-1405, USPL

Norepinephrine

(Levophed)

 

 

Standard drip = 4mg in 500 ml D5W/NS

Max conc. 64 mcg/ml

30 hrs/ 9 days

CP, PR1163-1164, USPM

 

Octreotide

(Sandostatin)

 

14 days

in CRT

500 mcg/250 ml

in NS(2 mcg/ml)

Max conc 5 mcg/ml

48 hrs/NA

 

D5W is stable for 24 hrs

CP, TR#1169-1170

Ondansetron

(Zofran)

 

 

9-16 mg/50 ml

in NS or D5W

48 hrs/14 days

*USPL,TR#1173-1175

Premixed by Hospira stable 30 days after over wrap removed

Pamidronate

30 mg /10 ml SW

90 mg /10 ml SW

24 hr (4°C)

30-90 mg dose

in 250-1000 ml D5W

48 hrs/14 days

Do not mix with calcium containing solutions, including D5LR or LR

NS can be use diluents but stable only 24 hrs. CP, USPL

Pantoprazole

(Protonix)

 

 

40-80 mg in NS or D5W

100 ml

30 hrs/9 days

Does not require filtration.

CP,USPM

Penicillin G

(Potassium)

(Sodium)

5 MU/ 8.2 ml SW

20 MU/ 33 ml SW

(0.5 MU/ML)

7 days (4°C)

 

0-2 MU/50 ML

2.1-4 MU/100 ML

4.1-10 MU/250 ML

IN NS or D5W

24 hrs/ 7 days

 

(1.7mEq K+/ MU Potassium)

(2 mEq Na+/MU Sodium)

CP, see attached file

Phenylephrine

(Neo-synephrine)

 

 

Standard drip = 10 mg in 250 ml NS/D5W(40 mcg/ml)

Conc. range 40-200 mcg/ml

48 hrs/48 hrs

TR#1259-1260, USPL

Phenytoin

(Dilantin)

 

 

101-1000mg/ml

in 50 mlNS

2 hrs/NA

Mix immediately prior to use. Administer with 0.22 micron filter.

Do not use Dextrose, Do not refrigerate.

TR#1264

Phytonadione(Vit K)

(Aqua-Mephyton)

 

 

1-20 mg/50ml

in D5W or NS

24 hrs/24 hrs

Protect from light.

CP

Potassium chloride

 

 

1-40 meq/100-1000 ml

in D5W or NS

48 hrs/14 days

Premixed by Hospira stable 30 days after over wrap removed

USPL

Potassium phospate

 

 

1-20 mM/250 ml

21-40 mM/500 ml

in NS or D5W

24 hrs/24 hrs

Do not use with LR

CP

Pipercillin / Tazobactam

(Zosyn)

2.25gm/10ml SW

3.375 m/l15 ml SW

4.5 gm/20ml SW

24 hrs(CRT)

48 hrs(4°C)

2.25-4.5g

In 100ml NS or D5W

48 hrs/14 days

Stable 14 days in refrigerator after thawing.

CP,USPL

Prochlorperazine (compazine)

 

 

11-40mg in NS or D5W

(50-1000 ml)

24 hrs/24 hrs

Protect from light. May give IV slow push if less than 10 mg

TR#1317-1318

Quinupristin/Dalfo-pristin

(Synercid)

500 mg/ 5ml

in SW or D5W

30 min refrig.

250ml D5W IVPB

desired conc. : 2mg/ml

5 hrs/54 hrs

Incompatible with NS.

Send each dose with D5W 50 ml flush bag. PI

Rifampin (Rifadin)

600mg/10ml SWFI

24hrs (CRT)

0-600mg in 500 ml

0-600 mg in 100 ml

4 hrs/NA in D5W

24 hrs/NA in NS

Protect from light/heat

100 ml infuse over 30 min or 500 ml infuse over 3 hrs per PI

Rocronium

(Zemuron)

 

60 days(CRT)

Standard drip : 250mg in 250 ml In NS/D5W(1 mg/ml)

Conc. range 1-5 mg/ml

24 hrs/NA

LD 0.6-1.2mg/kg

MD 8-12mcg/kg/mins

PI, TR#1375

Sodium Bicarbonate

 

 

1) 50-200 meq/1L

2) 182 meq/ 1182ml (conc:154 meq/ml)

IN Sterile water/D5W (standard infusion)

30 hrs/9 days

NS is stable for 24 hrs

Data in file, USPM

Thiamine

 

 

100mg/50ml

In D5W or NS

24 hrs/24 hrs

Tr#1448-1449

Tigecycline

(Tygacil)

5.3 ml of NS or D5W

6 hrs(CRT)

50-100mg in

100ML NS or D5W

 

24 hrs/48 hrs

Max Conc.= 1 mg/ml

TR#1470, PI

Tobramycin

 

 

 

4 days(4°C)

24 hours(CRT)

All doses in 100 ml

NS or D5W

48 hrs/14 days

TR#1476-1477, USPL

Premixed by Hospira stable 30 days after over wrap removed

Valproate Sodium

(Depacon)

 

 

0-1g in 50 ml

D5W or NS

2 days/NA

Maximum infusion rate = 20 mg/min

TR#1503-1504, USPL

Vancomycin

(Vancocin)

1 gm/20 ml SW

 

9 days

(4°C)

<5 mg/ml

D5W/NS IVPB

30 hrs/9 days

Compounded oral vancomycin liquid is stable for 75 days in FRI

USPM,TR#1550, date in file

Vasopressin

(Pitressin)

 

 

Standard drip = 100 units in D5W or NS (1units/ml)

Use immediately

Stability data is not available

IM#1368

Vecuronium

(Norcuron)

10mg/10ml SW

24hrs SW(4°C)

Standard drip : 50mg/500ml in D5W/NS

(Conc. 1 mg/ml)

24 hrs/ 24 hrs

Compatible with D5W, NS,LR

PI, TR#1524

Voriconazole

(VFEND I.V.)

200 mg/19 ml SW

24 hr (4°C)

Further dilution in D5W or NS to 0.5 -5 mg/ml is required

30 hr/ 9 days

Vial contains vacuum to ease reconstitution process.

CP, USPM

Zoledronic Acid

(Zometa)

 

24 hr (4°C)

Reconstitute w/ 5ml SW. Further dilute in D5W/NS 100 ml for infusion

NA/24 hrs

Do not mix with calcium containing solutions such as D5LR or LR.

PI

 

Pharmacy Phone Numbers
Memorial Pharmacy (Glenwood) 423-495-8380
Memorial Hixson Pharmacy 423-495-7137
Stat 423-495-7470
Outpatient 423-495-8981
Chemo 423-495-7475
Surgery 423-495-8779

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