Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Bolus: Dilute in 100 ml D5W at a maximum rate of 25 mg/min (usually given over 20-30 min).

Infusion: 1 gram/1000 ml D5W premix

Standard Concentration: 1 mg/ml

Premixed theophylline is 800 mg/1000 ml D5W

Theophylline 800 mg = Aminophylline 1000 mg and premixed drip considered to be “1:1”

LD: 6 mg/kg diluted then 0.1-1 mg/kg/hr

24 hrs

NS – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Bolus: 150 mg/100 ml D5W (glass or bag)

Infusion: 600 mg/600 ml D5W

Standard Concentration: 1 mg/ml

MAX CONCENTRATION: 2 mg/ml

Bolus: over 10 min, then 1 mg/min x 6 hours, then 0.5 mg/min x 18 hours

** Check with MD before decreasing rate **

Use in-line filter

PVC 2 hours;

polyolefin glass 24 hrs

NS is NOT recommended;

DO NOT USE

evacuated container

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 125 mg/125 ml NS

Concentration: 1 mg/ml

(may show slight haziness – repeat inversion of bag x 1 minute – DO NOT SHAKE)

Initial dose:

2 mcg/kg/min

(adjust for hepatic impairment – see PPI)

96 hrs REF or RT if protected from light;

24 hours in ambient light (REF or RT)

D5W - same

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 400 mcg + 96 ml NS

Concentration: 4 mcg/ml

Shake gently.

Do NOT change concentration or volume on this drip – send multiple bags if requested instead.

Bolus: 1 mcg/kg over 10 minutes, then 0.2-0.7 mcg/kg/hr

Withdraw bolus from bag

48 hrs

D5W – 48 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 100 mg/100 ml NS

(ADD-Vantage)

Standard Concentration: 1 mg/ml

LD: 0.25 mg/kg bolus over 2 minutes, then

5-15 mg/hr

24 hrs if mixed. ADD-Vantage 30 days

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 500 mg/250 ml D5W premix

Concentration: 2,000 mcg/ml (2 mg/ml)

MAX concentration: 5,000 mcg/ml (5 mg/ml) have been administered to humans per PPI

(1.25 gm/250 ml)

2-20 mcg/kg/min

40 mcg/kg/min have been used, but this increases risk of toxicity.

24 hrs

14 days after removed from Abbott overwrap

NS – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 800 mg/500 ml D5W premix

Concentration: 1,600 mcg/ml (1.6 mg/ml)

MAX concentration: 3,200 mcg/ml

(3.2 mg/ml) 800 mg/250 ml

Low: 2-5 mcg/kg/min

Med: 5-30 mcg/kg/min

High: 30 mcg/kg/min

Doses > 20 mcg/kg/min decrease renal perfusion.

48 hrs

7 days after removing from Abbott overwrap.

NS – 48 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 2 mg/250 ml NS

Concentration: 8 mcg/ml

Double Conc: 4 mg/250 ml NS (16 mcg/ml)

Quad Conc: 8 mg/250 ml NS (32 mcg/ml)

Low: 1-2 mcg/min

Med: 2-10 mcg/min

High: 10-16 mcg/min

48 hrs

D5W – 48 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 2.5 gm/250 ml NS premix

Concentration: 10 mg/ml

Do NOT give 2.5 gm vials UNDILUTED.

MAX Concentration: 10 gm/250 ml (40 mg/ml) per Abbott info.

LD: 500 mcg/kg

From the ready-to-use vial (10 mg/ml) over 1 minute.

Infusion: 50 mcg/kg/min titrated up to maximum of 200 mcg/kg/min – per PPI.

24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 10 mg/250 ml NS

Concentration: 40 mcg/ml

Fluid restricted pts: Can give 10 mg/100 ml

NS (100 mcg/ml) Mosby 2003 IV medications.

Initial dose: 0.03-0.1 mcg/kg/min and increase every 15 mins by 0.05-0.1 mcg/kg/min based on response.

Max recommended dose: 1.7 mcg/kg/min

24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 25,000 units/500 ml D5W

Concentration: 50 units/ml

Also, 25,000 units/500 ml 0.45% NaCl

Concentration: 50 units/ml

Per weight based protocol

90 days after removing from Braun overwrap.

D5W

or

0.45% NaCl

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 250 units/250 ml NS

Concentration: 1 unit/ml

RN to flush 50 ml through tubing to saturate sites that will adsorb insulin.

No filter.

24 hrs

N/A

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution:  1 mg/250 ml D5W

Concentration:  4 mcg/ml

Double Conc:  2 mg/250 ml (8 mcg/ml)

Quadruple Conc:  4 mg/250 ml (16 mcg/ml)

Maximum Conc:  25 mg/250 ml D5W (100 mcg/ml)

0.05 to 10 mcg/min

24 hrs

NS – pH is higher and at pH > 6 = drug is degraded.

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 200 mg/160 ml NS

(total volume = 200 ml) Conc: 1 mg/ml

May give 20 mg undiluted over > 2 minutes and may repeat 40-80 mg every 10 minutes until effect or 300 mg maximum total dose.

Maximum Dilution: 375 mg(75 mls)+25 ml NS

(total volume = 100 ml) Conc: 3.75 mg/ml

Alternative infusion:

2 mg/minute via continuous infusion

72 hrs

D5W – 72 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 100 mg/250 ml NS

Concentration: 0.4 mg/ml (400 mcg/ml)

Give bolus + infusion.

Dose is weight and renal dependent – see package insert.

24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 2 gm/500 ml D5W premix

Concentration: 4 mg/ml

MAX concentration: 4 gm/250 ml (16 mg/ml)

1-4 mg/minute

(20-50 mcg/kg/min).

Do not exceed 4 mg/min

30 days after removing overwrap.

NS – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 24 mg/120 ml D5W (GLASS ONLY) Concentration: 0.2 mg/ml

Mix as follows: 24 mg lorazepam (12 ml) + 14 ml SWFI – add this mixture to 94 ml D5W to make total volume of 120 ml.

Mixing in GLASS ONLY will help prevent precipitation. PPT problems thought to be due to propylene glycol preservative.

DO NOT DOUBLE CONCENTRATE –

WILL PPT!

Use microdrip set and titrate to achieve adequate sedation.

Up to 5-10 mg/hr has been used, but titrate to lowest effective dose. Usually START at 1 mg/hr.

24 hrs in GLASS

Protect from light.

NS – 24 hrs

GLASS – NS can be used as diluent but more problems with PPT.

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 50 mg/40 ml NS

(total volume will be 50 ml)

Concentration: 1 mg/ml

Titrate to effect.

Typical adult LD = 0.5-4 mg over several minutes, then titrate infusion to lowest effective dose

(usually 1-7 mg/hr for maintenance).

24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 20 mg/100 ml D5W premix

Concentration: 0.2 mg/hr (200 mcg/ml)

**withdraw bolus from infusion bag.

MAX Conc: 100 mg/250 ml NS or D5W

Concentration: 0.4 mg/hr (400 mcg/ml)

Loading dose:

50 mcg/kg (drawn from bag) over 10 minutes, then infusion of 0.5 mcg/kg/min.

72 hrs

30 days after removed from Abbott overwrap.

NS - 72 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 25 mg + 240 ml NS (total volume = 250 ml) Conc: 0.1 mg/ml

MAX Conc: 0.5 mg/ml

*Max Conc must be administered via central line*

Initiate 5 mg/hr. May increase by 2.5 mg/hr every 5-15 min to a max of 15 mg/hr. After reaching BP goal, decrease to 3 mg/hr.

24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 50 mg/250 ml GLASS premix

Concentration: 0.2 mg/ml (200 mcg/ml)

MAX Conc: 250 mg/250 ml D5W or NS

Concentration: 1 mg/ml

5-20 mcg/min titrate to response.

NO FILTER

MFG exp date on bottles

NS – GLASS

24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution:  50 mg/250 ml D5W

Concentration:  0.2 mg/ml (200 mcg/ml)

Must be diluted.  Wrap in provided opaque material to protect from light.

Maximum Conc:  200 mg/250 ml D5W

(0.8 mg/ml) (800 mcg/ml) per Abbott info.

Company only supports our standard dilution of 50 mg/250 ml D5W (0.2 mg/ml).

0.3-10 mcg/kg/min.  Never exceed 10 mcg/kg/min.

Cyanide toxicity can occur with as little as 2 mcg/kg/min.

Measure blood thiocyanate levels daily if dose is 3 mcg/kg/min

(1 mcg/kg/min in the anuric patient).

24 hours if properly protected.

NS – not recommended by mfg.

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 4 mg/500 ml D5W

Concentration: 8 mcg/ml

Maximum Concentration: 32 mg/250 ml D5W

Concentration: 128 mcg/ml (per Abbott info)

0.5 – 1 mcg/min up to maximum of 30 mcg/min; adjust to maintain desired BP range (usually 2-4 mcg/minute)

24 hours

May dilute in D5NS, but plain NS not recommended by mfg

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 500 mcg/250 ml NS

Concentration: 2 mcg/ml

(Check with MD if starting dose > 25 mcg/hr – endogenous somatostatin was used in studies at 250 mcg/hr and this is NOT the somatostatin analog)

GI bleed:  25-50 mcg/hr (usual dose)

GI tumor:  25-50 mcg/hr

24 hours

D5W - 24 hours

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution:  20 units/1000 ml LR

Concentration:  20 milliunits/ml (0.02 units/ml)

0.5 – 1 milliunits/min and titrate

24 hrs

NS – 24 hrs

D5W – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 100 mg (100 ml)/100 ml NS

Concentration: 0.5 mg/ml (total volume 200 ml)

MUST BE INTUBATED WITH MECHANICAL SUPPORT FOR VENTILATION

LD: 0.03-0.1 mg/kg

MD: 0.06-0.1 mg/kg/hr

48 hr

(Monitor with peripheral nerve stimulator)

D5W – 48 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 10 mg/250 ml D5W

Concentration: 0.04 mg/ml (40 mcg/ml)

Double Conc: 20 mg/250 ml (80 mcg/ml)

Quadruple Conc: 40 mg/250 ml (160 mcg/ml)

Maximum Conc: 250 mg/250 ml

(1 mg/ml or 1,000 mcg/ml) per Abbott info

Severe hypotensive shock or drug-related hypotension: 100-180 mcg/min; maintain 40-60 mcg/min, titrating to desired effect

48 hrs

NS – 24 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 1 gm/250 ml NS

Concentration: 4 mg/ml

LD: 200-1,000 mg in 50-100 ml NS over 30 minutes

Infusion: 1-4 mg/min up to 6 mg/min

24 hrs

D5W – 8 hrs

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 1 gm/100 ml (10 mg/ml)

Change bottle and tubing every 12 hours.

Name brand Diprivan does NOT contain sulfites. Generic DOES CONTAIN SULFITES.

5-50 mcg/kg/min

Do NOT filter.

1 ml = 0.1 gm fat = 1.1 kcal

12 hrs

N/A

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 100 units/100 ml NS

Concentration: 1 unit/ml

Bleeding: 0.2-1 unit/min

Shock (adjuvant dose): 0.01-0.04 unit/min

24 hrs

D5W

Mixing & Standard Concentration

Dosing

Exp

Alt Diluent

Standard Dilution: 50 mg/450 ml NS

(total volume = 500 ml)

Concentration: 0.1 mg/ml (100 mcg/ml)

MUST BE INTUBATED WITH MECHANICAL SUPPORT FOR VENTILATION

Intubation:

80-100 mcg/kg then

50-100 mcg/kg/hr (may be preferred in pts with renal failure)

24 hrs

(Monitor with peripheral nerve stimulator)

D5W – 24 hrs