THERAPEUTIC SUBSTITUTION

CNS STIMULANTS

Modafinil (Provigil) Dosage:

Adults:

ADHD (unlabeled use): 100-300 mg once daily

Narcolepsy, obstructive sleep apnea/hypopnea syndrome: 200 mg single dose in AM

Shift Work Sleep Disorder (SWSD): Initial: 200 mg as single dose taken ~1 hr prior to start of work shift

Note: Doses of 400 mg/day, given as single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit.

Armodafinil (Nuvigil) Dosage:

Adults:

Narcolepsy:  150-250 mg once daily in the morning

Obstructive sleep apnea/hypopnea syndrome (OSAHS):  150-250 mg once daily in the morning; 250 mg was not shown to have any increased benefit over 150 mg

Shift work sleep disorder (SWSD): 150 mg given once daily ~1 hour prior to work shift