Nephrotoxicity

• Tubular and glomerular necrosis associated with parenteral (IM) use.
• Restrict use to infants with staphylococcal pneumonia or empyema due to susceptible organisms.
• Use only where adequate laboratory facilities are available and constant supervision of patient is possible.
• Avoid concurrent nephrotoxic drugs(e.g. streptomycin, kanamycin, polymixin B, colistin, neomycin)
• Monitor renal function at baseline and daily during therapy
• Do not exceed recommended daily dose
• Maintain fluid intake and urinary output at proper levels to avoid kidney toxicity.