Filtered Drugs - 2024
Filtered Medications
NAV Top A B C D E F G H I J K L M N O P R S T U V W X Y Z FN*

Filtered Drugs - 2024 PolicyReference last updated:
10/06/2025
A generic (Brand)AdminPrep
 abatacept (Orencia)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding filter.10
  Abraxane - see PACLitaxel, protein-bound
  Adakveo - see crizanlizumab-tmca
 ado-trastuzumab emtansine (Kadcyla)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line PES filter.11
 agalsidase beta (Fabrazyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line low-protein-binding filter; do not use a filter during preparation.12
  Aldurazyme - see laronidase
 alglucosidase alfa (Lumizyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line low-protein-binding filter; do not use a filter during preparation.13
 alpha-1 proteinase inhibitor (Aralast)Admin: N/A
Filter size: N/A
Administration: Filters not required by manufacturer. All brand names have been checked, but only the specified brand name products (Glassia, Prolastin C Liquid, Zemaira) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.
 alpha-1 proteinase inhibitor (Glassia)Admin: 5 micronPrep: 5 micron
Filter size: 5 micron (preparation and administration)
Preparation: Use the sterile filter needle provided by the manufacturer to transfer the solution to the infusion container.
Administration: Administer with an in-line filter.14 All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.
 alpha-1 proteinase inhibitor (Prolastin C Liquid)Admin: 5-15 micron
Filter size: 5-15 micron
Administration: Administer with an infusion filter.15 All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.
 alpha-1 proteinase inhibitor (Zemaira)Admin: 5 micronPrep: 15 micron
Filter size: 15 micronb (preparation), 5 micron (administration),
Preparation: Use the filter vial transfer set provided by the manufacturer during preparation.16
Administration: Administer with an in-line filter.5,7 All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.
  Alphanate - see antihemophilic factor VIII/Von Willebrand factor complex
  AmB-D - see amphotericin B deoxycholate
  AmBisome - see amphotericin B liposomal
 amino acids (Aminosyn II, Aminosyn-PF, Clinimix, Clinimix E, Clinisol, Plenamine, Premasol, ProSol, Synthamin, Travasol, TrophAmine)Admin: 0.22 micron
Filter size: See comments
Administration: ASPEN and the INS recommend a 1.2 micron filter for both lipid-containing and lipid-free PN solutions.8,9
IMH Comment: TPN (non-lipid containing): Use a 0.22 micron inline filter (stocked in storeroom).
 amino acids, electrolytes, dextrose, and lipid injectable (Kabiven, Perikabiven)Admin: 1.2 micon
Filter size: 1.2 micron
Administration: Administer with an in-line filter.17,18 An air-eliminating filter is recommended for lipid-containing PN solution.6
  Aminosyn - see amino acids
 amiodarone (Nexterone)Admin: See comments
Filter size: See comments
Administration: Administer with an in-line filter.19 The manufacturer does not provide a filter size recommendation. One study suggests no loss of potency with the use of a 0.22 micron cellulose ester membrane filter.5-7 FOOTNOTE: Both the specified branded product and the conventional generic product require filtration.c
 amivantamab (Rybrevant)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding, in-line PES filter.20
  Amondys 45 - see casimersen
 amphotericin B cholesteryl sulfate (Amphotec)Admin: N/A
Filter size: N/A
Administration: Only the amphotericin B liposomal (AmBisome) product requires the user to provide a filter.
 amphotericin B deoxycholate (AmB-D, Amphocin, Fungizone)Admin: 0.1 micron or larger
Filter size: 0.1 micron or larger
Administration: Only the amphotericin B liposomal (AmBisome) product requires the user to provide a filter. An in-line filter (1 micron or larger) may be used during administration of amphotericin B desoxycholate.180-182
 amphotericin B liposomal (AmBisome)Admin: 1 micron or largerPrep: 5 micron
Filter size: 5 micron (preparation), 1 micron or larger (administration)
Preparation: Use the 5 micron filter provided by the manufacturer during preparation.
Administration: An in-line membrane filter may be used for administration.21 FOOTNOTE: Only the specified amphotericin B product requires the user to provide a filter.d Amphotericin B lipid complex (Abelcet) should be prepared using the filter needle provided by the manufacturer.179
 andexanet alfa (Andexxa)Admin: 0.2-0.22 micron
Filter size: 0.2-0.22 micron
Administration: Administer with a PES or equivalent low-protein-binding in-line filter.22
  Andexxa - see andexanet alfa
 anifrolumab (Saphnelo)Admin: 0.2-15 micron
Filter size: 0.2-15 micron
Administration: Administer with a sterile, low-protein-binding, in-line or add-on filter.23
 ansuvimab (Ebanga)Admin: 1.2 micron
Filter size: 1.2 micron
Administration: Administer with an in-line filter extension set.24
  Anthim - see obiltoxaximab
 antihemophilic factor VIII/Von Willebrand factor complex (Alphanate, Humate P, Wilate)Prep: 15 micron
Filter size: 15 micronb
Preparation: Use the filter vial transfer set provided by the manufacturer.25-27 The manufacturer of Humate P states that another double-ended needle and vented filter spike can be used for reconstitution in place of the filter vial transfer set.26
 antithymocyte globulin (Thymoglobulin)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter.28
  Aralast - see alpha-1 proteinase inhibitor
  Atgam - see lymphocyte immune globulin, antithymocyte globulin
 atoltivimab, maftivimab, and odesivimab-ebgn (Inmazeb)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, in-line or add-on filter.29
  Aurlumyn - see iloprost
 avalglucosidase alfa (Nexviazyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line, low-protein-binding filter.30
 avelumab (Bavencio)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.31
  Avsola - see inFLIXimab-axxq
 axatilimab-csfr (Niktimvo)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, low-protein-binding in-line or add-on PES filter.32
B generic (Brand)AdminPrep
  BabyBIG - see botulism immune globulin IV
  BAT - see botulism antitoxin heptavalent
  Bavencio - see avelumab
 belatacept (Nulojix)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding filter.33
  Beleodaq - see belinostat
 belinostat (Beleodaq)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter.34
  Berinert - see C1 esterase inhibitor (human)
 bezlotoxumab (Zinplava)Admin: 0.2-5 micron
Filter size: 0.2-5 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line or add-on filter.35
  Bizengri - see zenocutuzumab-zbco
 blinatumomab (Blincyto)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: 24- or 48-hour infusion: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.36
7-day infusion: An in-line filter is not required.36
  Blincyto - see blinatumomab
 botulism antitoxin heptavalent (BAT)Admin: 15 micron
Filter size: 15 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.37
 botulism immune globulin IV (BabyBIG)Admin: 18 micron
Filter size: 18 micron
Administration: Administer with a sterile in-line or syringe-tip disposable filter.38
  Byooviz - see ranibizumaba
C generic (Brand)AdminPrep
 C1 esterase inhibitor (human) (Berinert, Cinryze, Haegarda)Prep: See comments
Filter size: 15 micronb (Berinert, Haegarda); 5 micronb (Cinryze)
Preparation: Use the filter vial transfer set provided by the manufacturer or another double-ended needle and vented filter spike during preparation.39-41
 cabazitaxel (Jevtana)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line filter.42
 casimersen (Amondys 45)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.43
 casirivimab and imdevimab (REGEN-COV)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, in-line or add-on PES filter.44
 cemiplimab-rwlc (Libtayo)Admin: 0.2-5 micron
Filter size: 0.2-5 micron
Administration: Administer with a sterile, in-line or add-on, low-protein-binding filter.6,45
 cetuximab (Erbitux)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with a low-protein-binding in-line filter.46
  Cimerli - see ranibizumaba
  Cinqair - see reslizumab
  Cinryze - see C1 esterase inhibitor (human)
 cipaglucosidase alfa-atga (Pombiliti)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter. Change the filter if it becomes blocked.47
 cladribine (Leustatin)Prep: 0.22 micron
Filter size: 0.22 micron
Preparation: Single daily dose injection: Use a sterile disposable hydrophilic syringe filter during preparation.48-50
7-day infusion: Use a sterile disposable hydrophilic syringe filter during preparation for both cladribine and diluent solutions as recommended by the manufacturer.48-50
  Clinimix - see amino acids
  Clinisol - see amino acids
  Clinolipid - see lipid emulsion
 clofarabine (Clolar)Prep: 0.2 micron
Filter size: 0.2 micron
Preparation: Use a sterile syringe filter during preparation prior to dilution.51
  Clolar - see clofarabine
  Columvi - see glofitamab-gxbm
  Cosela - see trilaciclib
  Cosentyx - see secukinumab
 cosibelimab-ipdl (Unloxcyt)Admin: 0.2-0.22 micron
Filter size: 0.2-0.22 micron
Administration: Administer with a sterile, in-line or add-on filter.52
  Cresemba - see isavuconazonium sulfate
 crizanlizumab-tmca (Adakveo)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, in-line filter. No incompatibility has been observed with filter membranes composed of PES (neutral and positively charged), polyamide (positively charged), and polysulphone.53
 crovalimab-akkz (Piasky)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.54
  Cyramza - see ramucirumab
 cysteine (Elcys)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter if given without lipid emulsion.55
  Cytogam - see cytomegalovirus immune globulin IV, (human)
 cytomegalovirus immune globulin IV, (human) (Cytogam)Admin: 15 or 0.2 micron
Filter size: 15 or 0.2 micron
Administration: Administer with an in-line filter.56
D generic (Brand)AdminPrep
 daratumumab (Darzalex)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line, sterile, non-pyrogenic, low-protein-binding PES filter.57
  Darzalex - see daratumumab
 defibrotide (Defitelio)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.58
  Defitelio - see defibrotide
  Dilantin - see phenytoin sodium, parenteral
 dostarlimab (Jemperli)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line or add-on filter.59
 durvalumab (Imfinzi)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, low-protein-binding in-line filter.60
E generic (Brand)AdminPrep
  Ebanga - see ansuvimab
 efgartigimod alfa (Vyvgart)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.61
  Elahere - see mirvetuximab soravtansine-gynx
  Elaprase - see idursulfase
  Elcys - see cysteine
  Elelyso - see taliglucerase alfa
  Elfabrio - see pegunigalsidase alfa-iwxj
 elosulfase alfa (Vimizim)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.62
 elotuzumab (Empliciti)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding filter.63
  Elzonris - see tagraxofusp-erzs
 emapalumab-lzsg (Gamifant)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.64
 emicizumab (Hemlibra)Prep: 5 micron
Filter size: 5 micron
Preparation: Use a transfer needle with filter to withdraw from the vial. The needle should be sterile, stainless steel, with a Luer lock, 18 gauge x 1.5 inch, single bevel or semi-blunted tip, single-use, latex-free, and non-pyrogenic.65
  Empliciti - see elotuzumab
  Enhertu - see fam-trastuzumab deruxtecan-nxki
  Enjaymo - see sutimlimab-jome
 epoprostenol sodium (Flolan, Veletri)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter.66,67
 eptinezumab-jjmr (Vyepti)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, in-line or add-on filter.68
  Erbitux - see cetuximab
 eteplirsen (Exondys 51)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.69
 evinacumab-dgnb (Evkeeza)Admin: 0.2-5 micron
Filter size: 0.2-5 micron
Administration: Administer with a sterile, in-line or add-on filter.70
  Evkeeza - see evinacumab-dgnb
  Exondys 51 - see eteplirsen
F generic (Brand)AdminPrep
  Fabrazyme - see agalsidase beta
 fam-trastuzumab deruxtecan-nxki (Enhertu)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line, PES or polysulfone filter.71
  Flolan - see epoprostenol sodium
 fosdenopterin hydrobromide (Nulibry)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a filter.72
  Fungizone - see amphotericin B deoxycholate
G generic (Brand)AdminPrep
 gallium dotatate GA-68 (Netspot)Prep: 0.2 micron
Filter size: 0.2 micron
Preparation: Use a sterile self-venting filter during preparation according to the generator system-specific reconstitution instructions provided in the package insert.73
 gallium GA-68 gozetotide (Illuccix, Locametz)Prep: 0.2 micron
Filter size: 0.2 micron
Preparation: Use a sterile self-venting filter during preparation according to the generator system-specific reconstitution instructions provided in the package insert.74,75
 galsulfase (Naglazyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter, do not use a filter during preparation.76
  Gamifant - see emapalumab-lzsg
  Gammagard S/D - see immune globulin IV
 gemtuzumab ozogamicin (Mylotarg)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line PES filter.77
  Glassia - see alpha-1 proteinase inhibitor
 glofitamab-gxbm (Columvi)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, in-line filter. No incompatibility has been observed with filters made of PES or polysulfone.78
 golimumab (Simponi aria)Admin: 0.22 micron or smaller
Filter size: 0.22 micron or smaller
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.79 FOOTNOTE: A prefilled syringe formulation is also available under a different brand name (Simponi).e
 golodirsen (Vyondys 53)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.80
H generic (Brand)AdminPrep
  Haegarda - see C1 esterase inhibitor (human)
 hemin (Panhematin)Admin: 0.45 micron or smaller
Filter size: 0.45 micron or smaller
Administration: Administer with an in-line filter.5,7,81
  Hemlibra - see emicizumab
 human plasma proteins (Octaplas)Admin: See comments
Filter size: See comments
Administration: Administer with an in-line filter.82 The manufacturer does not provide a filter size recommendation,but following standard blood product filtering procedures can be considered since this is a plasma-based product.8,82
  Humate P - see antihemophilic factor VIII/Von Willebrand factor complex
I generic (Brand)AdminPrep
 ibritumomab tiuxetan (Zevalin)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with a low-protein-binding in-line filter.83
 idursulfase (Elaprase)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.84
  Illuccix - see gallium GA-68 gozetotide
 iloprost (Aurlumyn)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line filter.85
  Imfinzi - see durvalumab
  Imjudo - see tremelimumab
 immune globulin IV (Gammagard S/D)Admin: 15 micron
Filter size: 15 micron
Administration: Administer Gammagard S/D with the infusion set provided by the manufacturer or another filter-containing administration set.86 All other products do not require filtration. FOOTNOTE: All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.a
  Imuldosa - see ustekinumab-srlf
 inebilizumab (Uplizna)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, low-protein-binding, in-line filter.87
  Inflectra - see inFLIXimab-dyyb
 inFLIXimab (Remicade)Admin: 1.2 micron or smaller
Filter size: 1.2 micron or smaller
Administration: Administer with a sterile non-pyrogenic, low-protein-binding in-line filter.88-91
 inFLIXimab-abda (Renflexis)Admin: 1.2 micron or smaller
Filter size: 1.2 micron or smaller
Administration: Administer with a sterile non-pyrogenic, low-protein-binding in-line filter.88-91
 inFLIXimab-axxq (Avsola)Admin: 1.2 micron or smaller
Filter size: 1.2 micron or smaller
Administration: Administer with a sterile non-pyrogenic, low-protein-binding in-line filter.88-91
 inFLIXimab-dyyb (Inflectra)Admin: 1.2 micron or smaller
Filter size: 1.2 micron or smaller
Administration: Administer with a sterile non-pyrogenic, low-protein-binding in-line filter.88-91
  Inmazeb - see atoltivimab, maftivimab, and odesivimab-ebgn
  Intralipid - see lipid emulsion
 ipilimumab (Yervoy)Admin: 0.2 or 1.2 micron
Filter size: 0.2 or 1.2 micronb
Administration: Administer with a sterile non-pyrogenic, low-protein-binding in-line filter.92 Ipilimumab is compatible with 0.2 and 1.2 micron PES filters and 0.2 micron nylon filters.b
 isatuximab (Sarclisa)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter (PES, polysulfone, or nylon).93
 isavuconazonium sulfate (Cresemba)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic in-line filter.5,94
 ixabepilone (Ixempra kit)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with an in-line filter.95
  Ixempra kit - see ixabepilone
J generic (Brand)AdminPrep
  Jemperli - see dostarlimab
  Jevtana - see cabazitaxel
K generic (Brand)AdminPrep
  Kabiven - see amino acids, electrolytes, dextrose, and lipid injectable
  Kadcyla - see ado-trastuzumab emtansine
  Kanuma - see sebelipase alfa
  Keytruda - see pembrolizumab
  Kimmtrak - see tebentafusp-tebn
L generic (Brand)AdminPrep
  Lamzede - see velmanase alfa-tycv
 laronidase (Aldurazyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter; do not use a filter during preparation.96
 lecanemab-irmb (Leqembi)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.97
  Leqembi - see lecanemab-irmb
 letermovir (Prevymis)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line PES filter.98
  Leustatin - see cladribine
  Libtayo - see cemiplimab-rwlc
 lipid emulsion (Clinolipid, Intralipid, Nutrilipid, Omegaven, Smoflipid)Admin: 1.2 micron
Filter size: 1.2 micron
Administration: An in-line filter should be used when administering lipid emulsion, both alone and as part of an admixture.8,9,99-104
IMH Comment: 1.2 micron filter required, will be sent from pharmacy with each bag (along with a fat emulsion IV set).
  Locametz - see gallium GA-68 gozetotide
 loncastuximab tesirine (Zynlonta)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding, in-line or add-on filter.105
  Loqtorzi - see toripalimab-tpzi
  Lumizyme - see alglucosidase alfa
  Lutathera - see lutetium Lu 177 dotatate
 lutetium Lu 177 dotatate (Lutathera)Prep: Not available
Filter size: Not available
Preparation: Use a filtered 20 gauge x 2.5 cm needle during preparation.106
 lymphocyte immune globulin, antithymocyte globulin (Atgam)Admin: 0.2-1 micron
Filter size: 0.2-1 micron
Administration: Administer with an in-line filter.107
M generic (Brand)AdminPrep
 mannitolAdmin: 0.2 micron
Filter size: See comments
Administration: Administer with an in-line filter when infusing concentrated mannitol (20% or more) due to the potential for crystal formation; some resources state to administer with an in-line filter for concentrations of 15% or more.5,7 No current manufacturer provides a filter size recommendation.108-111 One source currently suggests a filter size between 0.2 and 5 microns.7
IMH Comment: Use a 0.2 micron filter
  Margenza - see margetuximab-cmkb
 margetuximab-cmkb (Margenza)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding, PES in-line or add-on filter.112
  Mepsevii - see vestronidase alfa-vjbk
 methacholine (Provocholine)Prep: 0.22 micron
Filter size: 0.22 micron
Preparation: Use a sterile, bacterial-retentive filter during preparation when transferring solution from each vial (at least 2 mL) to a nebulizer.113
 mirvetuximab soravtansine-gynx (Elahere)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line PES filter.114
 mogamulizumab-kpkc (Poteligeo)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with a sterile, low-protein-binding in-line filter.115
  Mylotarg - see gemtuzumab ozogamicin
N generic (Brand)AdminPrep
  Naglazyme - see galsulfase
  Netspot - see gallium dotatate GA-68
  Nexterone - see amiodarone
  Nexviazyme - see avalglucosidase alfa
  Niktimvo - see axatilimab-csfr
 nivolumab (Opdivo)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.116
 nivolumab and relatlimab-rmbw (Opdualag)Admin: 0.2-1.2 micron
Filter size: 0.2-1.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter made of PES, nylon, or PVDF.117
  Noxafil - see posaconazole
  Nulibry - see fosdenopterin hydrobromide
  Nulojix - see belatacept
  Nutrilipid - see lipid emulsion
O generic (Brand)AdminPrep
 obiltoxaximab (Anthim)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with an in-line filter.118
 ocrelizumab (Ocrevus)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line filter.119
  Ocrevus - see ocrelizumab
  Octaplas - see human plasma proteins
 olipudase alfa (Xenpozyme)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter made of PES or polytetrafluoroethylene.120
  Omegaven - see lipid emulsion
  Onpattro - see patisiran
  Opdivo - see nivolumab
  Opdualag - see nivolumab and relatlimab-rmbw
  Orencia - see abatacept
  Otulfi - see ustekinumab-aauz
P generic (Brand)AdminPrep
 PACLitaxel (Taxol)Admin: 0.22 micron or smaller
Filter size: 0.22 micron or smaller
Administration: Administer conventional PACLitaxel with an in-line filter.
 PACLitaxel, protein-bound (Abraxane)Admin: N/A
Filter size: N/A
Administration: A filter is not needed for the albumin-bound formulation (Abraxane).121,122 FOOTNOTE: The currently marketed brand name product (Abraxane) does not require filtration.f
  Panhematin - see hemin
 panitumumab (Vectibix)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a low-protein-binding in-line filter.123
 patisiran (Onpattro)Admin: 1.2 micronPrep: 0.45 micron
Filter size: 0.45 micron (preparation), 1.2 micron (administration)
Preparation: Use a sterile PES syringe filter during preparation.
Administration: Administer with a PES in-line filter.124
 pegunigalsidase alfa-iwxj (Elfabrio)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, low-protein-binding in-line filter.7,125
 pembrolizumab (Keytruda)Admin: 0.2-5 micron
Filter size: 0.2-5 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line or add-on filter.126
  Pemgarda - see pemivibart
 pemivibart (Pemgarda)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.127
  Perikabiven - see amino acids, electrolytes, dextrose, and lipid injectable
 phenytoin sodium, parenteral (Dilantin)Admin: 0.22 micron
Filter size: 0.22-0.55 micron
Administration: If giving as an intermittent infusion, administer with an in-line filter.128
IMH Comment: For IV infusions, use a 0.22 micron in-line filter.
  Piasky - see crovalimab-akkz
  Plenamine - see amino acids
 polatuzumab vedotin-piiq (Polivy)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding, in-line or add-on filter.129
  Polivy - see polatuzumab vedotin-piiq
  Pombiliti - see cipaglucosidase alfa-atga
 posaconazole (Noxafil)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with a PES or PVDF in-line filter.6,130
  Poteligeo - see mogamulizumab-kpkc
 pozelimab-bbfg (Veopoz)Admin: 0.2-5 micron
Filter size: 0.2-5 micron
Administration: Administer with a sterile, in-line or add-on filter.131
  Premasol - see amino acids
  Prevymis - see letermovir
  Prolastin C Liquid - see alpha-1 proteinase inhibitor
  ProSol - see amino acids
  Provocholine - see methacholine
  Pyzchiva - see ustekinumab-ttwe
R generic (Brand)AdminPrep
 ramucirumab (Cyramza)Admin: 0.22 micron
Filter size: 0.22 micron
Administration: Administer with a protein-sparing filter.132
 ranibizumaba (Byooviz, Cimerli, Susvimo)Admin: 5 micronPrep: 5 micron
Filter size: 5 micron
Preparation: Use a 19 gauge x 1.5 inch sterile filter needle during preparation.
Administration: Use a non-filter needle for the intravitreal injection.133-135
 ravulizumab-cwvz (Ultomiris)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a low-protein-binding in-line filter.136
  REGEN-COV - see casirivimab and imdevimab
  Remicade - see inFLIXimab
  Remodulin - see treprostinil
  Renflexis - see inFLIXimab-abda
 reslizumab (Cinqair)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter; Cinqair is compatible with PES, PVDF, nylon, and cellulose acetate in-line filters.137
 retifanlimab-dlwr (Zynyz)Admin: See comments
Filter size: See comments
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding PES, PVDF, or cellulose acetate in-line or add-on 0.2 to 5 micron filter. A 15 micron mesh in-line or add-on filter can also be used.138
  Rybrevant - see amivantamab
S generic (Brand)AdminPrep
  Saphnelo - see anifrolumab
  Sarclisa - see isatuximab
 sebelipase alfa (Kanuma)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.139
 secukinumab (Cosentyx)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.140
 siltuximab (Sylvant)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line PES filter.141
  Simponi aria - see golimumab
  Smoflipid - see lipid emulsion
 spesolimab-sbzo (Spevigo)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter. No incompatibility has been observed with filters composed of PES (neutral and positively charged) and polyamide (positively charged).142
  Spevigo - see spesolimab-sbzo
  Stelara - see ustekinumaba
  Steqeyma - see ustekinumab-stba
  Susvimo - see ranibizumaba
 sutimlimab-jome (Enjaymo)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line PES filter.143
  Sylvant - see siltuximab
  Synthamin - see amino acids
T generic (Brand)AdminPrep
 tagraxofusp-erzs (Elzonris)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a PES in-line filter; manufacturer recommends attaching the filter while preparing (priming) the infusion set.144
 taliglucerase alfa (Elelyso)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.145
  Taxol - see PACLitaxel
 tebentafusp-tebn (Kimmtrak)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.146
 temsirolimus (Torisel)Admin: See comments
Filter size: 5 micron or smaller (in-line filter), 0.2-5 micron (end-set filter)
Administration: Administer with an in-line PES filter or an end-set PES filter if an in-line filter is not available. Do not use both an in-line and an end-set filter.147
  Tepadina - see thiotepa
  Tepylute - see thiotepa
  Tevimbra - see tislelizumab-jsgr
 thiotepa (Tepadina, Tepylute)Admin: See comments
Filter size: 0.2147-151 or 0.22 micron 152,153
Administration: Administer with an in-line filter148-154; some generic manufacturers recommend filtering with a polysulfone membrane or triton-free mixed ester of cellulose/PVC filter prior to administration; solutions of generic thiotepa (10-300 µg/mL) did not adsorb to cellulose nitrite, cellulose acetate ester, or Teflon filters.6,7,153,154 FOOTNOTE: Both the specified branded product and the conventional generic product require filtration.c
  Thymoglobulin - see antithymocyte globulin
 tislelizumab-jsgr (Tevimbra)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line or add-on filter.155
 tisotumab vedotin (Tivdak)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with an in-line filter.156
  Tivdak - see tisotumab vedotin
 toripalimab-tpzi (Loqtorzi)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an aseptic in-line filter.157
  Torisel - see temsirolimus
  TPN - see amino acids
 trabectedin (Yondelis)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a PES in-line filter.158
  Travasol - see amino acids
 tremelimumab (Imjudo)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a sterile, low-protein-binding in-line filter.159
 treprostinil (Remodulin)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line filter.160-163
 trilaciclib (Cosela)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with an in-line filter made of PES, PVDF, or cellulose acetate.164
  TrophAmine - see amino acids
U generic (Brand)AdminPrep
  Ultomiris - see ravulizumab-cwvz
  Unloxcyt - see cosibelimab-ipdl
  Uplizna - see inebilizumab
 ustekinumab (Stelara)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170 FOOTNOTE: All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.a
 ustekinumab-aauz (Otulfi)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170
 ustekinumab-auub (Wezlana)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170
 ustekinumab-srlf (Imuldosa)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170
 ustekinumab-stba (Steqeyma)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170
 ustekinumab-ttwe (Pyzchiva)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding in-line filter.165-170
V generic (Brand)AdminPrep
  Vectibix - see panitumumab
 velaglucerase alfa (Vpriv)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a low-protein-binding in-line filter.171
  Veletri - see epoprostenol sodium
 velmanase alfa-tycv (Lamzede)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.172
  Veopoz - see pozelimab-bbfg
 verteporfin (Visudyne)Admin: 1.2 micron
Filter size: 1.2 micron
Administration: Administer with an in-line filter.173
 vestronidase alfa-vjbk (Mepsevii)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a low-protein-binding in-line filter.174
  Vimizim - see elosulfase alfa
  Visudyne - see verteporfin
  Vpriv - see velaglucerase alfa
  Vyepti - see eptinezumab-jjmr
  Vyloy - see zolbetuximab-clzb
  Vyondys 53 - see golodirsen
  Vyvgart - see efgartigimod alfa
W generic (Brand)AdminPrep
  Wezlana - see ustekinumab-auub
  Wilate - see antihemophilic factor VIII/Von Willebrand factor complex
X generic (Brand)AdminPrep
  Xenpozyme - see olipudase alfa
Y generic (Brand)AdminPrep
  Yervoy - see ipilimumab
  Yondelis - see trabectedin
Z generic (Brand)AdminPrep
  Zaltrap - see ziv-aflibercept
 zanidatamab-hrii (Ziihera)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron
Administration: Administer with a filter. The infusion solution is compatible with PES or PVDF filters.175
  Zemaira - see alpha-1 proteinase inhibitor
 zenocutuzumab-zbco (Bizengri)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: Administer with a sterile, non-pyrogenic, low-protein-binding PES in-line filter.176
  Zevalin - see ibritumomab tiuxetan
  Ziihera - see zanidatamab-hrii
  Zinplava - see bezlotoxumab
 ziv-aflibercept (Zaltrap)Admin: 0.2 or 0.22 micron
Filter size: 0.2 or 0.22 micron 6,174
Administration: Administer with a PES filter. Do not use filters made of PVDF or nylon.177
 zolbetuximab-clzb (Vyloy)Admin: 0.2 micron
Filter size: 0.2 micron
Administration: An in-line filter is recommended. The infusion solution is compatible with PES or polysulfone filters.178
  Zynlonta - see loncastuximab tesirine
  Zynyz - see retifanlimab-dlwr
  generic (Brand)AdminPrep
 Footnotes
Note. ASPEN = American Society of Parenteral and Enteral Nutrition; INS = Infusion Nurses Society; IV = intravenous; PES = polyethersulfone; PN = parenteral nutrition; PVDF = polyvinylidene fluoride.
a All brand names have been checked, but only the specified brand name product(s) require filtration. The most up-to-date package insert should be periodically reviewed for the most current recommendations.
b Filter size not specified in product labeling; size information was obtained via personal communication with manufacturer.
c Both the specified branded product and the conventional generic product require filtration.
d Only the specified amphotericin B product requires the user to provide a filter. Amphotericin B lipid complex (Abelcet) should be prepared using the filter needle provided by the manufacturer.179 An in-line filter (1 micron or larger) may be used during administration of amphotericin B desoxycholate.180-182
e A prefilled syringe formulation is also available under a different brand name.
f The currently marketed brand name product does not require filtration.

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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