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ACETAMINOPHEN
|
- Tylenol Arthritis is a slow-release tablet and may not be crushed.
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|
ACETAZOLAMIDE
|
- Acetazolamide 500 mg capsules (sustained release) may not be crushed
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ALBUTEROL (ORAL)
|
- Do not crush slow-release tablets
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|
ALENDRONATE
|
- mucous membrane irritant.
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|
ALFUZOSIN
|
- Should not be crushed or chewed.
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ALPRAZOLAM
|
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ALVIMOPAN
|
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AMOXICILLIN
|
- Extended release tablet may not be crushed
|
|
AMOXICILLIN-CLAVULANATE
|
- Do not crush XR dosage form, but it may be broken in half. Liquid dosage forms may vary from XR formulation in dose and frequency of administration.
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AMPHETAMINE-DEXTROAMPHETAMINE
|
- Capsules are extended release; they may be opened and contents taken without crushing or chewing. Contents may be administered via NG tube using appropriate liquid.
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ASPIRIN
|
- Do not crush enteric coated tablets
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ATOMOXETINE
|
- contents can be irritating to the eyes.
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|
BENZONATATE
|
- Swallow whole and do not crush. Temporary anesthesia of the oral mucosa could occur and choking could result.
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BISACODYL
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- tablets are enteric coated
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BOSENTAN
|
- women who are, or may become pregnant, shuld not handle crushed or broken tablets
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BUDESONIDE (ORAL)
|
- Capsules may be opened and contents taken without crushing or chewing in soft food. Contents may be administered via NG and washed down with appropriate fluid.
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BUPROPION
|
- Extended release and sustained release dosage forms may not be crushed.
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CARBAMAZEPINE
|
- Do not crush slow-release capsules. Capsules may be opened and contents taken without crushing or chewing, and administered in soft food, or washed down an NG tube. Extended release tablets must be swallowed whole.
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CARBIDOPA-LEVODOPA
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- Extended release tablets. The tablets are scored and may be broken in half without affecting release characteristics.
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CARVEDILOL
|
- Capsules are extended-release & may not be crushed, but contents may be added to chilled applesauce if consumed immediately.
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CEFACLOR - NONFORMULARY
|
- Extended release tablet not to be crushed
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CEFUROXIME
|
- Due to taste, use oral suspension instead.
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CLARITHROMYCIN
|
- If DAW, Biaxin XL may not be crushed due to slow-release properties.
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CLONIDINE
|
- Slow release tablets may not be crushed.
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COLESTIPOL
|
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CYCLOBENZAPRINE
|
- Extended release capsules may not be crushed
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CYCLOPHOSPHAMIDE
|
- May be crushed but manufacturer recommends injection if unable to swallow
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DABIGATRAN
|
- Swallow whole; do not chew, break or open capsules. Capsule contents are not to be sprinkled over food or into beverages, or administered via feeding tubes.
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DARIFENACIN
|
- tablets are extended release
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DESVENLAFAXINE
|
- Slow release tablets may not be crushed.
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DEXLANSOPRAZOLE - NONFORMULARY
|
- Capsule may be opened and contents taken without crushing or chewing.
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DEXMETHYLPHENIDATE
|
- XR formulation is slow-release and may not be crushed. The capsule may be opened and contents mixed with soft food and taken without crushing or chewing. Contents may be washed down an NG tube with appropriate fluid.
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DEXTROMETHORPHAN-GUAIFENESIN
|
|
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DICLOFENAC
|
- Enteric coated and extended release tablets can not be crushed.
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DICLOFENAC-MISOPROSTOL
|
- Tablets are enteric coated and delayed-release
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DIDANOSINE
|
- Extended release capsules may not be crushed; use chewable tablets
|
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DILTIAZEM - SOME FORMULATIONS ARE NONFORMULARY
|
- Slow release capsules (Tiazac) may be opened & contents mixed with soft food without crushing or chewing, or administered via NG tube with appropriate fluid.
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DIPYRIDAMOLE-ASPIRIN
|
|
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DISOPYRAMIDE
|
- CR dosage form is extended release
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DIVALPROEX SODIUM
|
- Do not crush capsules or sprinkles - mucous membrane irritant. Liquid dosage forms are available, but the dose and frequency of administration may be different than that of the solid dosage form.
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DOCUSATE
|
- capsules or gelcaps due to taste
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DONEPEZIL
|
- Crushing the 23 mg tablet may significantly increase the rate of absorption; 5 mg and 10 mg tablets may be crushed
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DOXAZOSIN
|
- Extended Release tablets may not be crushed
|
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DOXYCYCLINE
|
- Film coated tablets may be broken in halves or thirds, but extended release capsules may not be crushed.
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DOXYLAMINE/PYRIDOXINE
|
|
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DULOXETINE
|
- Capsules are formulated to be slow-release
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DUTASTERIDE
|
- Do not chew or open capsules; Should not be handled by pregnant women or women who may become pregnant
|
|
DUTASTERIDE/TAMSULOSIN
|
- Mucous membrane irritant; Should not be handled by pregnant women or women who may become pregnant.
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|
ERGOCALCIFEROL
|
- Do not crush - liquid filled capsule
|
|
ERGOLOID MESYLATES
|
- Do not crush the capsules - liquid filled
|
|
ERYTHROMYCIN - SOME FORMULATIONS ARE NONFORMULARY
|
- Do not crush solid dosage forms. Capsules may be opened and contents taken without crushing or chewing in soft foods. Capsule contents may be administered via NG and washed down with appropriate fluid.
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ESOMEPRAZOLE - NONFORMULARY
|
- Enteric coated - may not be crushed
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FELODIPINE (NONFORMULARY)
|
- Felodipine tablets are extended release.
|
|
FENOFIBRIC ACID - NONFORMULARY
|
- Slow release capsules may not be crushed
|
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FENTANYL
|
- Do not crush lozenge/lollipop - delivery system requires slow dissolution in mouth. Buccal tablets are to be swallowed whole.
|
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FERROUS GLUCONATE - NONFORMULARY
|
|
|
FERROUS SULFATE
|
- Enteric coated - Liquid dosage forms are available if unable to swallow whole.
|
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FERROUS SULFATE-ASCORBIC ACID (NONFORMULARY)
|
|
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FESOTERODINE
|
|
|
FEXOFENADINE/PSEUDOEPHEDRINE - NONFORMULARY
|
|
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FINASTERIDE
|
- Women who are, or may become pregnant should not handle crushed or broken tablets.
|
|
FLUOXETINE
|
- Do not crush the enteric coated dosage form (Prozac Weekly.)
|
|
FLUVASTATIN (NONFORMULARY)
|
- Do not crush the extended release tablet.
|
|
FLUVOXAMINE
|
|
|
GABAPENTIN
|
|
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GALANTAMINE
|
- Do not crush extended release capsules.
|
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GANCICLOVIR
|
|
|
GLIPIZIDE
|
- Do not crush or split extended release tablets (XL formulation.)
|
|
GUAIFENESIN
|
- 600 mg tablets are extended release tablets.
|
|
GUAIFENESIN-PHENYLEPHRINE
|
|
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GUAIFENESIN-PSEUDOEPHEDRINE
|
- Solid dosage forms are extended release
|
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GUANFACINE
|
|
|
HAEMOPHILUS B CONJUGATE VACCINE
|
|
|
HYDROMORPHONE
|
- Crushing, chewing, or dissolving slow release tablets can cause rapid release and absorption of a potentially fatal dose
|
|
HYDROXYUREA
|
- Exposure to powder may cause skin toxicities.
|
|
HYOSCYAMINE
|
- Do not crush the extended release dosage forms
|
|
IBANDRONATE
|
- Do not chew or suck tablets due to potential for oropharyngeal ulceration.
|
|
IBUPROFEN
|
- Do not crush tablets due to taste - a liquid dosage form is available
|
|
IMATINIB
|
- Tablet may be broken in half, but do not crush due to taste. May be dissolved in water or apple juice.
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INDINAVIR
|
- capsule may be opened and mixed with pureed fruit.
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|
INDOMETHACIN
|
- Extended release capsules can not be crushed, but may be opened and contents administered without chewing or crushing in soft food. the contents of the extended release capsule may be administered via NG with appropriate fluid
|
|
ISOSORBIDE DINITRATE
|
- Do not crush extended release or sublingual tablets.
|
|
ISOSORBIDE MONONITRATE
|
- Imdur may not be crushed, but is scored and may be split in half; Ismo is crushable
|
|
ISOTRETINOIN
|
|
|
ISRADIPINE - NONFORMULARY
|
|
|
KETOCONAZOLE
|
|
|
LAMOTRIGINE
|
- Slow-release tablets may not be crushed
|
|
LANSOPRAZOLE
|
- Capsules are enteric coated
|
|
LEVETIRACETAM
|
- Due to taste, do not crush any solid dosage forms.
|
|
LITHIUM
|
- Do not crush tablets (extended release)
|
|
LOPINAVIR/RITONAVIR
|
- Tablets should be swallowed whole, and not chewed, crushed, or broken.
|
|
LORATADINE-PSEUDOEPHEDRINE
|
|
|
LOVASTATIN (NONFORMULARY)
|
- Extended release tablets should be swallowed whole, and may not be crushed, chewed, or cut
|
|
LUBIPROSTONE
|
- Extended release capsules should be swallowed whole, and may not be crushed or chewed
|
|
MESALAMINE
|
- Do not crush extended release capsules or enteric coated tablets.
|
|
METFORMIN
|
- Slow release dosage forms should not be crushed.
|
|
METHYLPHENIDATE
|
- Do not crush extended release tablets or capsules. Capsules may be opened and contents taken without crushing or chewing in soft food. Capsule contents may be administered via NG using appropriate fluid.
|
|
METOPROLOL
|
- Extended release tablets may not be crushed, but may be broken in half without affecting drug release.
|
|
METRONIDAZOLE
|
- Do not crush Flagyl ER (slow-release formulation).
|
|
MITOXANTRONE
|
|
|
MORPHINE
|
- Do not crush extended release tablets or capsules. Capsules may be opened and contents taken without crushing or chewing. Liquid dosage forms are available but may differ in dose and frequency of administration from solid dosage
|
|
MYCOPHENOLATE
|
- Do not crush solid dosage forms. According to ISMP, mycophenolate has teratogenic potential, and direct contact with skin may enhance tumor production.
|
|
NAPROXEN
|
- Do not crush enteric coated or extended release dosage forms
|
|
NIACIN
|
- Do not crush extended release tablets or capsules.
|
|
NICARDIPINE
|
- Do not crush extended release capsules.
|
|
NICOTINE
|
|
|
NIFEDIPINE
|
- Do not crush tablets due to extended-release formulation.
|
|
NISOLDIPINE - NONFORMULARY
|
|
|
NITROGLYCERIN
|
- Do not crush extended release capsules or sublingual tablets
|
|
OMEGA-3 POLYUNSATURATED FATTY ACIDS
|
- Contents of capsule may erode walls of styrofoam or plastic materials
|
|
OMEPRAZOLE - NONFORMULARY FOR ADULTS
|
- Extended Release/Enteric coated
|
|
ORPHENADRINE
|
- Do not crush sustained release tablets
|
|
OXYBUTYNIN
|
- XL tablets not to be chewed, divided or crushed
|
|
OXYCODONE
|
|
|
PALIPERIDONE
|
- Tablets are extended release
|
|
PANCRELIPASE
|
- Enteric-coated capsules may not be crushed. Capsules may be opened and the contents taken without crushing or chewing. Contents may be administered via NG tube using appropriate fluid
|
|
PANTOPRAZOLE
|
- Do not crush. Lansoprazole is an automatic substition for proton pump inhibitors ordered
|
|
PAPAVERINE
|
- Do not crush sustained release capsules
|
|
PAROXETINE
|
|
|
PENTOXIFYLLINE
|
- Extended release - swallow whole
|
|
PIROXICAM
|
|
|
POTASSIUM BICARBONATE - NONFORMULARY
|
- Must be dissolved in liquid
|
|
POTASSIUM BICARBONATE/POTASSIUM CHLORIDE - NONFORMULARY
|
|
|
POTASSIUM CHLORIDE
|
- Do not crush KCL tablets; liquid dosage forms are available if needed. K-Dur can be dissolved in water to form a tasteless solution.
|
|
POTASSIUM CITRATE
|
- Tablet is wax coated to prevent upper GI release.
|
|
PREDNISONE
|
- Slow-release dosage form may not be crushed; delayed release is dependent upon an intact coating.
|
|
PROCAINAMIDE
|
|
|
PROPAFENONE
|
- Extended release dosage forms may not be crushed
|
|
PROPRANOLOL
|
- Extended release dosage forms may not be crushed
|
|
PSEUDOEPHEDRINE
|
|
|
PYRIDOSTIGMINE
|
- Do not crush extended release dosage form. A liquid dosage form is available.
|
|
QUETIAPINE
|
- Extended release dosage forms may not be crushed
|
|
QUINIDINE
|
- Extended release dosage forms can not be crushed
|
|
RABEPRAZOLE
|
- Extended Release and not to be crushed
|
|
RALOXIFENE
|
- due to taste and teratogenic potential. Avoid direct contact with skin.
|
|
RANOLAZINE
|
|
|
RISEDRONATE
|
- Chewed, crushed, or sucked tablets may cause oropharyngeal irritation . Atelvia is slow-release and tablet coating is important part of delayed release.
|
|
RISPERIDONE
|
|
|
RITONAVIR
|
- Crushing has resulted in decreased bioavailability. A liquid form is available.
|
|
RIVAROXABAN
|
- may be crushed, but must be administered within 4 hours
|
|
ROPINIROLE
|
- Do Not Crush XL dosage form
|
|
SALSALATE
|
|
|
SEVELAMER
|
- Tablets expand in liquid if broken or crushed - do not crush.
|
|
SIROLIMUS
|
- Liquid dosage form is available.
|
|
SOLIFENACIN
|
|
|
SULFASALAZINE
|
- Enteric-coated (tablets) Entabs should be swallowed whole.
|
|
TAMSULOSIN
|
- Capsule contents are enteric coated - see comments
|
|
TEMOZOLOMIDE
|
|
|
TENOFOVIR
|
|
|
THEOPHYLLINE
|
- Do not crush extended release tablets or capsules; capsules contain beads that dissolve throughout the GI tract.
|
|
TOLTERODINE
|
- Detrol LA is a slow-release formulation and cannot be crushed.
|
|
TOPIRAMATE
|
- Not to be crushed due to taste. Capsules may be opened and contents taken without crushing or chewing, mixed in soft food, or flushed down NG with appropriate fluid.
|
|
TRAMADOL
|
- Crushing of extended release tablet may cause a potentially fatal overdose of tramadol.
|
|
VALPROIC ACID
|
- Do not crush capsules - mucous membrane irritant. Liquid dosage forms are available, but the dose and frequency of administration may be different than that of the solid dosage form.
|
|
VENLAFAXINE
|
- Extended release capsules may not be crushed
|
|
VERAPAMIL
|
- Sustained release tablets may not be crushed, but are scored and may be broken in half. Sustained release capsules may be opened and contents taken without crushing or chewing.
|
|
ZILEUTON
|
- The extended release tablet is not crushable.
|
|
ZOLPIDEM
|
|
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