UNC Health Medication Formulary
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UNC Health Medication Formulary
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denosumab

denosumab
Drug Name Form Strength ARHS Blue Ridge Caldwell Chatham Johnston Lenoir Medical Center Nash Pardee Rex Rockingham Southeastern Wayne Youth Behavioral Health
Denosumab (Jubbonti) SOLUTION, SUBCUTANEOUS 60 mg/mL (1 mL)          
Denosumab (Prolia) SOLUTION, SUBCUTANEOUS 60 mg/mL (1 mL)        
Denosumab (Wyost) SOLUTION, SUBCUTANEOUS 70 mg/mL (120 mg/1.7 mL)              
Denosumab (Xgeva) SOLUTION, SUBCUTANEOUS 70 mg/mL (120 mg/1.7 mL)          

UNC Health

System Formulary Restriction:

Denosumab (Prolia): restricted to patients in outpatient or clinic encounters (ie, no inpatient use) who meet the following 
criteria:

    • Continuation of therapy in patients who previously received Prolia
    • Initiation of therapy in patients with insurance restrictions that require Prolia, or do not cover Jubbonti 

Denosumab (Xgeva): restricted to patients in outpatient or clinic encounters (ie, no inpatient use) who meet the following 
criteria:

    • Continuation of therapy in patients who previously received Xgeva
    • Initiation of therapy in patients with insurance restrictions that require Xgeva, or do not cover Wyost

Treatment of Hypercalcemia of Malignancy in Adults Guideline

Med Center

UNC Medical Center Formulary Restrictions


Last updated: Dec. 16, 2025







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