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Medications listed are available on OH EPIC Formulary, unless otherwise noted.
Not all formulary medications are available at each facility. Please refer to your local pharmacy for available inventory.
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tbo-filgrastim

tbo-filgrastim
Drug Name Form Strength Infusion Center Available Restricted Non-formulary Ambulatory Available Interchange REMS
Granix SOLUTION, SUBCUTANEOUS 300 mcg/0.5 mL; 480 mcg/0.8 mL        
VIEW MORE Hemorrheologic Agents
CLASS
202400
Additional Information and Links

Restricted:

  • Inpatient formulary:
    • Releuko is the OH-preferred filgrastim biosimilar for all indications for adults and pediatrics EXCEPT:
      • Stem cell mobilization prior to (bone marrow) stem cell transplant
      • Colony stimulation post stem cell (bone marrow) transplantation
      • Pediatrics patients < 36 kg or requiring intravenous growth factor administration

 

If a filgrastim biosimilar/tbo-filgrastim (Granix) is ordered for one of the above exceptions, please initiate therapeutic interchange to filgrastim (Neupogen) at the same ordered dose.

 

If filgrastim (Neupogen), tbo-filgrastim (Granix), or any other filgrastim biosimilar is ordered besides filgrastim- AYOW (Releuko) for an indication not on the above list, please initiate the therapeutic interchange to filgrastim-AYOW (Releuko) at the same ordered dose.

 

  • Outpatient formulary:
    • Releuko is the OH-preferred filgrastim biosimilar. However, it is also driven by payer preference. 

 

Therapeutic Interchange:

Requested Dispensed

Exceptions
tbo-filgrastim (Granix) filgrastim-AYOW (Releuko)
  • Stem cell mobilization prior to (bone marrow) stem cell transplant
  • Colony stimulation post stem cell (bone marrow) transplantation
  • Pediatrics patients < 36 kg or requiring intravenous growth factor administration
Last updated: Dec. 9, 2024

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