Medications listed are available on OH EPIC Formulary, unless otherwise noted. Not all formulary medications are available at each facility. Please refer to your local pharmacy for available inventory.
Indication: treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive
Service Line: Neurology
Formulary Location: Outpatient
Service location: Outpatient Infusion, Home Infusion
Patient Population: Adult
Prior Authorization Required: Yes
Restriction/Criteria of Use (all will apply, unless specified):
Diagnosis of generalized MG with a positive serological test for anti-AChR antibodies
Patient has a Myasthenia Gravis Foundation of America (MGFA) Clinical Classification of class II, III, or IV disease at the start of therapy
Patient has Myasthenia Gravis-Activities of Daily Living (MG-ADL) score ≥ 5
Must not be used with other biologic therapies for myasthenia gravis or immunoglobulin therapy
Trial and failure, contraindications or intolerance to at least one (1) immunosuppressive therapy (e.g., corticosteroids, methotrexate, azathioprine, cyclophosphamide, cyclosporine, mycophenolate mofetil, or tacrolimus)
Six month trial and failure of eculizumab or ravulizumab