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Medications listed are available on OH EPIC Formulary, unless otherwise noted.
Not all formulary medications are available at each facility. Please refer to your local pharmacy for available inventory.
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defibrotide

defibrotide
Drug Name Form Strength Infusion Center Available Restricted Non-formulary Ambulatory Available Interchange REMS
Defitelio SOLUTION, INTRAVENOUS 80 mg/mL          
VIEW MORE von Willebrand Factor-related Antithrombotics
CLASS
201210
Additional Information and Links

OH Epic Formulary restricted to:

  • Indication: treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT)
  • Service line: Bone Marrow Transplant
  • Formulary location: Inpatient
  • Service location: Inpatient
  • Patient population: Adults, pediatrics
  • Restriction/Criteria of Use (all will apply unless specified)
    • High suspicion of hepatic VOD/SOS per criteria listed in BMT-P-506 SOP.
    • Patient is hemodynamically stable (on no more than 1 vasopressor agent).
    • Patient is not on any systemic anticoagulant/fibrinolytic agents or agents decreasing platelet aggregation.
    • Patient is not experiencing clinically significant bleeding/active bleeding.
Last updated: Aug. 29, 2024

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