Give 40-80mg (1-2 vials) of digoxin-Fab initially and if the patient is still symptomatic after 60 min, repeat the 40-80 mg (1-2 vials) dose, and sooner if patient is clinically unstable..
For cardiac arrest or other life-threatening signs or symptoms, a larger neutralizing dose (10-20 vials = 400-800 mg) of digoxin-Fab is indicated
Dosing Guidelines: