prothrombin complex concentrate
Order via ANTITHROMBOTIC REVERSAL order set (order set 1941)
Reversal Guidelines:
Reversal in adult patients on warfarin, dabigatran, rivaroxaban, or abixaban: See Reversal Guideline 900.5010
Pediatric: Reversal of warfarin: See Reversal Guideline 900.5866
Massive Transfusion Protocol, see protocol 915.6150 and Pharmacologic Adjuncts for Massive Transfusion
5/2022: P&T Approval of fixed dosing of Kcentra for warfarin reversal for major bleeding or emergent surgery and fixed dose Kcentra for factor Xa-inhibitor reversal for major bleeding.
Other Guidelines:
Anticoagluation Management while on ECMO, see protocol 922.5063
May have limited inventory. See Antidote Policy 916.3804
Correcting coagulopathy using ROTEM: see Trauma Guideline 901.5001
For further information, see Drug Monograph.
How to Enter and Verify Blood Factor Product Orders: See Pharmacist Tip Sheet
Order via ANTITHROMBOTIC REVERSAL order set (order set 1941)
Reversal Guidelines:
Reversal in adult patients on warfarin, dabigatran, rivaroxaban, or abixaban: See Reversal Guideline 900.5010
Pediatric: Reversal of warfarin: See Reversal Guideline 900.5866
Massive Transfusion Protocol, see protocol 915.6150 and Pharmacologic Adjuncts for Massive Transfusion
5/2022: P&T Approval of fixed dosing of Kcentra for warfarin reversal for major bleeding or emergent surgery and fixed dose Kcentra for factor Xa-inhibitor reversal for major bleeding.
Other Guidelines:
Anticoagluation Management while on ECMO, see protocol 922.5063
May have limited inventory. See Antidote Policy 916.3804
Correcting coagulopathy using ROTEM: see Trauma Guideline 901.5001
For further information, see Drug Monograph.
How to Enter and Verify Blood Factor Product Orders: See Pharmacist Tip Sheet