Baricitinib is Formulary, Restricted to approval by Infectious Diseases,

For patients with COVID-19: Restricted to Infectious Disease approval 8 am-5pm. ID consult team will assess the patient for appropriate inclusion/exclusion criteria. If after ID approval hours, please contact the ID team the next day for approval between 8 am- 5pm. 

Inclusion Criteria

• • Laboratory confirmed COVID-19
  • Age ≥ 18 years old
  • Receiving concomitant corticosteroid therapy (at least dexamethasone 6mg daily or equivalent)
  • Recent hospitalization (within 3 days) and/or ICU admission within 24 hours
  • Rapidly increasing oxygen needs (must require ≥5 L of supplemental O2 to maintain SaO2 ≥ 92%)
  • CRP ≥ 75 mg/L (ONE time value only at time of decompensation, do not recheck)
  • Limit to 14 days or until hospital discharge, whichever is sooner

Exclusion Criteria

• • On other JAK inhibitor or biologic DMARD, previous receipt of tocilizumab during admission
  • Uncontrolled bacterial, fungal or non-SARS-CoV-2 viral infection
  • History of untreated latent tuberculosis or active tuberculosis infection
  • eGFR < 15 mL/min/1.73m2 or HD
  • ALC < 200 cells/µL or ANC < 500 cells/µL
  • Elevated AST/ALT > 5x ULN
  • Requiring high flow oxygen or non-invasive ventilation for longer than 48 hours
  • Mechanical ventilation or ECMO

• Micromedex
• CareNotes
• UpToDate
• Facts & Comparisons
• MedLinePlus (Patient Information)