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Esketamine
esketamine
DEA Class III VIEW MORE Antidepressants, Miscellaneous
Last updated: Apr. 28, 2026
- Black Box Warning: Sedation; Dissociation; Abuse and Misuse; and Surcidal Thoughts and Behaviors
- REMS: Spravato REMS-FDA REMS Info
- REMS: Legacy Health REMS Requirements-Esketamine
- Restricted Formulary Restricted Medication
Esketamine (Spravato) is a formulary restricted medication: use restricted to Unity and requires insurance pre-approval prior to use.
The goal of the Spravato REMS is to mitigate the risk of serious outcomes resulting from sedation and dissociation and respiratory depression caused by administration, and includes health care setting, patient, pharmacy and wholesaler-distributor requirements for dispensing.
See Legacy Health REMS Requirements for detail.