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dexmedetomidine

dexmedetomidine

Restricted Medications Cardiac Monitor (IV infusion)

Brand names: Precedex

Form	Strength
SOLUTION, INTRAVENOUS	20 mcg/5mL; 200 mcg/2mL; 200mcg/50mL premix; 400 mcg/100mL premix

Display Anxiolytics, Sedatives, and Hypnotics, Miscellaneous Class: 282492

Medication comments:

Warning: Pump Care Area Special Med!

dexmedetomidine should generally not be interrupted during procedures unless there is a specific physician order.

dexmedetomidine (Precedex) persistent agitation guidelines
For severe persistent agitation, begin infusion at 0.1 mcg/kg/hr. Titrate by 0.1 mcg/kg/hr every 30 min to 0 RASS score (alert and calm). Monitor for bradycardia and hypotension. Document RASS with EACH titration. Max dose = 1.4 mcg/kg/hr. Notify provider if patient is at maximum rate for Precedex and not at desired RASS score. Two hours with consistent infusion rate, decrease rate by 0.1 mcg/kg/hr every 15 minutes to evaluate for resolution of agitation symptoms.

dexmedetomidine (Precedex) persistent agitation guidelines

For severe persistent agitation, begin infusion at 0.1 mcg/kg/hr. Titrate by 0.1 mcg/kg/hr every 30 min to 0 RASS score (alert and calm). Monitor for bradycardia and hypotension. Document RASS with EACH titration. Max dose = 1.4 mcg/kg/hr. Notify provider if patient is at maximum rate for Precedex and not at desired RASS score. Two hours with consistent infusion rate, decrease rate by 0.1 mcg/kg/hr every 15 minutes to evaluate for resolution of agitation symptoms.

Per policy, these medications require cardiac and/or special monitoring. (KEY: "Y" = may be given as described on chart. "N" = may NOT be given except in Rapid Response/Code Blue situations or as otherwise described in Exceptions section of Policy.
generic (Brand) / Notes	CCU, OR, PACU, CCL, ED	PCU	2N (Tele)	1N (Tele), 3N (Tele)	Med/Surg (1N w/o Tele, 3N w/o Tele, 4N, 5N)	BirthPlace	SNF	ICS	OPS
dexmedetomidine (Precedex) IV infusion	Y	Y	N	N	N	N	N	N	N

Iredell Memorial Hospital ICU Adult Infusion Guidelines
The following orders are intended to provide a specific, safe, and effective means of initiating and titrating medications for critically ill patients. Physicians may modify doses and/or parameters as necessary pending patients' status. For all medications listed below, the responsible LIP is to be notified if unable to titrate or the maximum dose is reached andgoals of therapy are not met.
Drug Name	Onset	Preparation	Compatible fluids
dexmedetomidine (Precedex)	1 min	400 mcg/100 mls NS 200 mcg/50 mls NS	NS ONLY
Starting Dose for ICU Sedation		Titration Guidelines (for increasing and decreasing doses) with Maximum dose
Begin infusion at 0.4 mcg/kg/hr.		titrate by 0.1 mcg/kg/hr every 30 min to -2 RASS sedation score. Monitor for hypertension. Max dose = 1.4 mcg/kg/hr.

Last updated: Apr. 23, 2026

Look-Alike/Sound-Alike dexmedeTOMIDine confused with dexAMETHasone

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

This site is intended for the staff of Iredell Health System. While others may view accessible pages, Iredell Health System makes no warranty, express or implied, as to the use of this information outside of Iredell Health System. The content of this policy and procedure document serves as guidance to the delivery of quality patient care. Care providers are expected to exercise critical thinking and situational awareness skills, and in specific situations to take such action as is necessary for the delivery of quality patient care.