acyclovir
Drug Name | Form | Strength | Clinic Use Only | Inpatient Restrictions | Outpatient Restrictions | Non-Formulary |
---|---|---|---|---|---|---|
Acyclovir | CAPSULE, ORAL | 200 mg | ||||
Acyclovir Sodium | POWDER FOR INJECTION, INTRAVENOUS | 500 mg | ||||
Acyclovir Sodium | SOLUTION, INTRAVENOUS | 50 mg/mL | ||||
Acyclovir | SUSPENSION, ORAL | 200 mg/5 mL | ||||
Acyclovir | TABLET, ORAL | 400 mg; 800 mg |
HFH is currently experiencing a CRITICAL shortage of IV acyclovir.
To conserve supply, IV acyclovir will be restricted to patients with herpes meningitis or encephalitis.
Recommendations for HSV and VZV prophylaxis and treatment can be found in the transplant prophylaxis protocols and renal dosing guidelines, available in the OneHenry policy portal or the HFH antimicrobial stewardship website.
For reference, valacyclovir dosing by indication is included below:
Valacyclovir PO
Creatinine Clearance (mL/minute)
Herpes labialis
(for 2 doses)
1st episode genital HSV
(for 10 days)
Recurrent Genital HSV
(for 3 days)
Recurrent Genital HSV Suppression
Shingles/ VZV
(for 7 days for zoster rash)
≥ 50
2 gram PO every 12 hours
1 gram PO every 12 hours
500 mg every 12 hours OR
1 gm q 24h
1 gram PO every 24 hours
9 or fewer recurrences per year: 500 mg PO every 24 hours
1 gram PO every 8 hours
30 to 49
1 gram PO every 12 hours
1 gram PO every 12 hours
500 mg PO every 12h OR
1 gm q 24h
500 mg to 1 gram PO every 24 hours
1 gram PO every 12 hours
10 to 29
500 mg PO every 12 hours
1 gram PO every 24 hours
500 mg PO every 24 hours
500 mg PO every 48 hours
1 gram PO every 24 hours
< 10
500 mg PO every 24 hours
500 mg PO every 24 hours
500 mg PO every 24 hours
500 mg PO every 48 hours
500 mg PO every 24 hours
Hemodialysis (HD)
500 mg PO every 24 hours, schedule after HD on HD days
500 mg PO every 24 hours, schedule after HD on HD days
500 mg PO every 24 hours, schedule after HD on HD days
500 mg PO every 48 hours, schedule after HD on HD days
500 mg PO every 24 hours, schedule after HD on HD days
Valacyclovir PO (continued)
Creatinine Clearance (mL/minute)
Herpes labialis- HIV
(for 5 to 10 days)
Herpes labialis Suppression - HIV
Recurrent Genital HSV – HIV
(for 5 to 14 days)
≥ 50
1 gram PO every 12 hours
500 mg PO every 12 hours
1 gram PO every 12 hours
30 to 49
1 gram PO every 12 hours
500 mg PO every 12 hours
1 gram PO every 12 hours
10 to 29
1 gram PO every 24 hours
500 mg PO every 24 hours
1 gram PO every 24 hours
< 10
500 mg PO every 24 hours
500 mg PO every 24 hours
500 mg PO every 24 hours
Hemodialysis (HD)
500 mg PO every 24 hours, schedule after HD on HD days
500 mg PO every 24 hours, schedule after HD on HD days
500 mg PO every 24 hours, schedule after HD on HD days