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System Formulary Update
Anti-Parkinson’s Disease Agents
Situation
The anti-Parkinson’s disease agents class review and formulary standardization was approved at the December 2021 System Pharmacy and Therapeutics Committee meeting.
Background
The following medications were reviewed: amantadine, apomorphine, benztropine, bromocriptine, carbidopa, carbidopa/levodopa, carbidopa/levodopa/entacapone, entacapone, opicapone, pramipexole, ropinirole, rotigotine, tolcapone, trihexyphenidyl
Assessment/Recommendation
Changes effective: Tuesday, February 8, 2022
System P&T voted to include the following products on the UNC Health Medication Formulary:
- Amantadine IR capsule and oral solution
- Benztropine tablet
- Bromocriptine tablet
- Carbidopa/levodopa IR tablet, ER tablet, and oral extemporaneous solution
- Entacapone tablet
- Pramipexole IR tablet
- Ropinirole IR tablet
- Trihexyphenidyl tablet
Note: Stock of these formulary products may vary at individual entities
As a result, the following products will be removed from the UNC Health Medication Formulary
- Amantadine IR tablet, ER tablet, and ER capsule
- Apomorphine sublingual film and injection solution
- Benztropine injection solution
- Bromocriptine capsule
- Carbidopa tablet
- Carbidopa-levodopa ODT, ER capsule, and enteral suspension
- Carbidopa-levodopa-entacapone tablet
- Opicapone tablet
- Pramipexole ER tablet
- Ropinirole ER tablet
- Rotigotine transdermal patch
- Tolcapone tablet
- Trihexyphenidyl oral elixir
Non-formulary orders will be converted according to the following therapeutic interchange:
| Anti-Parkinson's Disease Agents | |
| Non-Formulary Order | Formulary Equivalent Order |
|
Amantadine IR tablet 100 mg two times daily |
Amantadine IR capsule 100 mg two times daily |
|
Carbidopa/levodopa/entacapone tablet 12.5 mg/50 mg/200 mg three times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg three times daily |
|
Carbidopa/levodopa/entacapone tablet 12.5 mg/50 mg/200 mg four times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg four times daily |
|
Carbidopa/levodopa/entacapone tablet 25 mg/100 mg/200 mg three times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg three times daily |
|
Carbidopa/levodopa/entacapone tablet 25 mg/100 mg/200 mg four times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg four times daily |
|
Carbidopa/levodopa/entacapone tablet 37.5 mg/150 mg/200 mg three times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg three times daily |
|
Carbidopa/levodopa/entacapone tablet 37.5 mg/150 mg/200 mg four times daily |
Carbidopa/levodopa IR tablet
Entacapone tablet 200 mg four times daily |
|
Carbidopa/levodopa/entacapone tablet 50 mg/200 mg/200 mg three times daily |
Carbidopa/levodopa IR tablet 50 mg/200 mg three times daily
Entacapone tablet 200 mg three times daily |
|
Carbidopa/levodopa/entacapone tablet 50 mg/200 mg/200 mg four times daily
|
Carbidopa/levodopa IR tablet 50 mg/200 mg four times daily
Entacapone tablet 200 mg four times daily |
|
Pramipexole ER tablet 0.375 mg once daily 0.75 mg once daily 1.5 mg once daily 2.25 mg once daily 3 mg once daily 3.75 mg once daily 4.5 mg once daily |
Pramipexole IR tablet 0.125 mg three times daily 0.25 mg three times daily 0.5 mg three times daily 0.75 three times daily 1 mg three times daily 1.25 mg three times daily 1.5 mg three times daily |
|
Ropinirole ER tablet 6 mg once daily 12 mg once daily 18 mg once daily 24 mg once daily |
Ropinirole IR tablet 2 mg three times daily 4 mg three times daily 6 mg three times daily 8 mg three times daily |