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System Formulary Update
GI (Colonoscopy) Preparation Agents Class Standardization
May 19, 2025

Situation: The Gastrointestinal (Colonoscopy) Preparation Agents class review and formulary standardization was approved at the April 2025 System Pharmacy and Therapeutics Committee meeting.

Background: The following medications were reviewed:

• Polyethylene glycol 3350 (Miralax) 238 g oral solution
• PEG 3350, sodium sulfate, sodium bicarbonate, sodium chloride, potassium chloride 4000 mL (GoLYTELY, Gavilyte, generic) oral powder for solution
• Sodium sulfate 17.5 g, potassium sulfate 3.13 g, magnesium sulfate 1.6 g (SUPREP) oral solution
• PEG 3350 100 g, sodium sulfate 9 g, sodium chloride 2 g, potassium chloride 1 g (PLENVU) powder packet
• PEG 3350 100 g, sodium sulfate 7.5 g, sodium chloride 2.69 g, potassium chloride 1.02 g, ascorbic acid 4.7 g, sodium ascorbate 5.9 g (MoviPrep) powder packet

Assessment/Recommendation: 

System P&T voted to include the following products on the UNC Health Medication Formulary:

• Polyethylene glycol 3350 238 g oral solution
• PEG 3350, sodium sulfate, sodium bicarbonate, sodium chloride, potassium chloride 4000 mL (GoLYTELY, Gavilyte, generic) oral powder for solution
• Sodium sulfate 17.5 g, potassium sulfate 3.13 g, magnesium sulfate 1.6 g (SUPREP) oral solution

Note: Stock of these formulary products may vary at individual entities

As a result, the following products will be removed from the UNC Health Medication Formulary

• Ascorbic Acid; Polyethylene Glycol 3350; Potassium Chloride; Sodium Ascorbate; Sodium Chloride; Sodium Sulfate (MoviPrep)

Formulary/Epic Changes will Go-Live on Tuesday, July 8th