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norEPINEPHrine

norEPINEPHrine
  • Restricted Medications Cardiac Monitor (IV)
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Levophed SOLUTION, INTRAVENOUS 4 mg/4 mL inj;4 mg/250 mL Soln; 8 mg/250 mL Soln      
Display alpha and beta-Adrenergic Agonists Class : 121212
Medication comments:
Warning: Pump Care Area Special Med!
norepinephrine should generally not be interrupted during procedures unless there is a specific physician order.
Per policy, these medications require cardiac and/or special monitoring.
(KEY: "Y" = may be given as described on chart. "N" = may NOT be given except in Rapid Response/Code Blue situations or as otherwise described in Exceptions section of Policy.
generic (Brand) / Notes CCU, OR, PACU, CCL, ED PCU 2N (Tele) 1N (Tele), 3N (Tele) Med/Surg (1N w/o Tele, 3N w/o Tele, 4N, 5N) BirthPlace SNF ICS OPS
norEPINEPHrine (Levophed)
IV Infusion vasopressor		 Y N N N N N N N N
Iredell Memorial Hospital ICU Adult Infusion Guidelines  
The following orders are intended to provide a specific, safe, and effective means of initiating and titrating medications for critically ill patients. Physicians may modify doses and/or parameters as necessary pending patients' status.For all medications listed below, the responsible LIP is to be notified if unable to titrate or the maximum dose is reached andgoals of therapy are not met.
Drug Name Onset Preparation Compatible fluids
norEPINEPHrine (Levophed) seconds 4 mg/250 mL
8 mg/250 mL		 NS or D5W
Starting Dose for ICU Sedation Titration Guidelines (for increasing and decreasing doses) with Maximum dose
Begin infusion at 2 mcg/min. titrate by 2 mcg/min every 5 min to keep MAP > 65. Max = 40 mcg/min.
Adult Extravasation Management
norEPINEPHrine (Levophed)
Agent type: Non-Chemotherapeutic
Vesicant/Irritant: Vesicant
Local Care: Warm compress
Antidote: Phentolamine injection, nitroglycerin topical 2% ointment, or terbutaline
Antidote link(s):
Comments: • Phentolamine preferred 1st line
Last updated: Aug. 27, 2025
  • Black Box Warnings Extravasation risk
  • Look-Alike/Sound-Alike norEPINEPHrine confused with ePHEDrine, EPINEPHrine
UpToDate Lexidrug

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