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glyBURIDE

glyBURIDE
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Glynase TABLET, ORAL micronized 3 mg      
Diabeta TABLET, ORAL 2.5 mg      
Display Sulfonylureas Class : 682020
Medication comments:
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: glyBURIDE (Diabeta, Glynase, Micronase)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Comments aka glibenclamide
Drug(s) sulfonylureas (all, including short- and longer-acting)
Rationale Sulfonylureas have a higher risk of cardiovascular events, all-cause mortality, and hypoglycemia than alternative agents. Sulfonylureas may increase the risk of cardiovascular death and ischemic stroke.
Among sulfonylureas, long-acting agents (e.g., glyBURIDE, glimepiride) confer a higher risk of prolonged hypoglycemia than short-acting agents (e.g., glipiZIDE).
Recommendation Avoid sulfonylureas as first- or second-line monotherapy or add-on therapy unless there are substantial barriers to the use of safer and more effective agents.
If a sulfonylurea is used, choose short-acting agents (e.g., glipiZIDE) over long-acting agents (e.g., glyBURIDE, glimepiride).
 Quality of evidence: Hypoglycemia: High
CV events and all-cause mortality: Moderate
CV death and ischemic stroke: Low, Strength of Recommendation: Strong
Last updated: Nov. 3, 2025
  • Look-Alike/Sound-Alike glyBURIDE confused with glipiZIDE
UpToDate Lexidrug

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