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fluconazole PO

fluconazole PO
  • Restricted Medications Indication limit
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Diflucan LIQUID, ORAL 50 mg/5 mL      
Diflucan TABLET, ORAL 100 mg; 150 mg; 200 mg      
Display Azoles Class : 081408
Medication comments:
Per policy, use of these medications is restricted as noted below:  
generic (Brand) Restrictions
fluconazole (Diflucan) If patient indication is for vulvovaginal candidiasis, dose and duration will be automatically adjusted to 150 mg PO x 1. If additional doses are needed, provider will need to re-order (recommended to reorder after 3 days if symptoms persist).
Per policy, these drugs are subject to renal dosing adjustments by pharmacy. 
Generic + Route
(Brand)
• Indications		 Usual Adult Dose
Comments		 Renal Dosage Adjustments
fluconazole IV/PO
(Diflucan©)		 100-800 mg q24h Administer 100% of the indication-specific loading initial dose recommended and then adjust daily dose
CrCl > 50: No adjustment necessary
CrCl ≤ 50: 50% of usual dose q24h
HD: same loading dose, then 50% q24h
USP <800> Hazardous Drug Assessment of Risk (AOR)
Per policy, these drugs are exempt from USP <800> handling requirements under normal circumstances.
The following outlines must be followed.
generic (Brand) Route
[Packaging: Manufacturer ⇒ Dispense]		 Activities
fluconazole (Diflucan) PO
[UD ⇒ UD]		  100 mg tablet
150 mg tablet
200 mg tablet (IMH)		 Stock @ IDBH? Y
NIOSH Table 2B↑
Pharmacy:
Receiving / Storage / Preparation

Exposure Risk: minimal
 • Handling/preparation PPE Requirements: n/a
• Receiving from Distributor: Standard
• Pharmacy Storage Area: Carousel
• Packaging/Reconstitution Location: n/a
• Compounding (Non-Sterile/Sterile) Location: n/a
• Omnicell Load: Yes
Transport • Transport (dose is placed inside a plastic sealable bag): Standard
Nursing:
Storage / Administration

Exposure Risk: low
 • Handling/administration PPE Requirements: via Mouth- Single pair of CX approved gloves
via Tube- double CX gloves and gown
Wash hands after handling
• Storage of Finished dose in Nursing Area/Procedural Area: Patient Med Drawer
Omnicell
• Signage on Patient Door Required: No
• Manipulation of Dosage Form: Standard
• Special Manipulation for Administration:
Disposal / Spills • Disposal of Drug Waste: Full-  blue bin 
Trace/packaging- trash
• Disposol of Used PPE: trash bin (inside plastic bag)
• Spill management: n/a
NIOSH Supplemental Information: case reports describe congenital abnormalies in infants exposed in utero to maternal fluconazole (400-800mg/d) during most or all of the 1st trimester, similar to those seen in animal studies
Reason for exemption of USP<800> Containment Requirements: Purchased in final dosage form; packaged as unit dose. Does not require additional manipulation for dispensing.
Last updated: May. 22, 2025
  • Renal Adjustment Policy fluconazole subject to adjustments by pharmacy.
  • Hazard.Drug Handling(USP 800) USP<800> Hazardous Drug / Assessment of Risk
UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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