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esterified estrogens-methylTESTOSTERone

esterified estrogens-methylTESTOSTERone
  • Restricted Medications Non-Formulary / Not-stocked
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Estratest H.S. TABLET, ORAL 0.625 mg / 1.25 mg      
Display Androgens, Estrogens Class : 680800, 681604
Medication comments:
USP <800> Hazardous Drug Assessment of Risk (AOR)
Per policy, these drugs are exempt from USP <800> handling requirements under normal circumstances.
The following outlines must be followed.
generic (Brand) Route
[Packaging: Manufacturer ⇒ Dispense]		 Activities
esterified estrogens and methylTESTOSTERone (Estratest HS) PO
[Bulk ⇒ Packager]		  0.625 mg/1.25 mg tablet Stock @ IDBH? N
NIOSH Table 2↑
Pharmacy:
Receiving / Storage / Preparation

Exposure Risk: low
 • Handling/preparation PPE Requirements: Single CX glove
Wash hands after handling
• Receiving from Distributor: Standard
• Pharmacy Storage Area: CSM
• Packaging/Reconstitution Location: Repacking area
• Compounding (Non-Sterile/Sterile) Location: n/a
• Omnicell Load: Yes
Transport • Transport (dose is placed inside a plastic sealable bag): Standard
Nursing:
Storage / Administration

Exposure Risk: low
 • Handling/administration PPE Requirements: Single pair of CX approved gloves. Wash hands after handling
• Storage of Finished dose in Nursing Area/Procedural Area: Omnicell
• Signage on Patient Door Required: No
• Manipulation of Dosage Form: Standard
• Special Manipulation for Administration: n/a
Disposal / Spills • Disposal of Drug Waste: Full-  Rx Destroyer , packaging- trash
• Disposol of Used PPE: trash bin (inside plastic bag)
• Spill management: n/a
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: esterified estrogens-methylTESTOSTERone (Estratest)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s) estrogens with or without progestins (includes natural and synthetic estrogen preparations)
Rationale Evidence of carcinogenic potential (breast and endometrium); lack of cardioprotective effect and cognitive protection in older women.
For women who start HRT at age 60 and older, the risks of HRT are greater than the benefits, as HRT is linked to a higher risk of heart disease, stroke, blood clots, and dementia.
Evidence indicates that vaginal estrogens for the treatment of vaginal dryness are safe and effective; women with a history of breast cancer who do not respond to nonhormonal therapies are advised to discuss the risks and benefits of low-dose vaginal estrogen (e.g., dosages of estradiol <25 mcg twice weekly) with their healthcare provider.
Recommendation Do not initiate systemic estrogen (e.g., oral tablets or transdermal patches). Consider deprescribing among older women already using this medication.
Vaginal cream or vaginal tablets: acceptable to use low-dose intravaginal estrogen for the management of dyspareunia, recurrent lower urinary tract infections, and other vaginal symptoms.
 Quality of evidence: Oral and patch: high
Vaginal cream or vaginal tablets: moderate, Strength of Recommendation: Oral and patch: strong
Topical vaginal cream or tablets: weak
 
Criteria 2: Potentially inappropriate medication use in older adults due to drug–disease or drug–syndrome interactions that may exacerbate the disease or syndrome. (Table 3)
Drug(s) ⇆ disease or syndrome estrogen, oral and transdermal (excludes intravaginal estrogen) ⇄ Urinary incontinence (all types) in women
Rationale Lack of efficacy.
Recommendation Avoid in women. See also recommendation on estrogen (Table 2)
 Quality of evidence: High, Strength of Recommendation: Strong
Last updated: Nov. 3, 2025
UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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