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ceftolozane-tazobactam

ceftolozane-tazobactam
  • Restricted Medications Infectious Disease Services use only
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Zerbaxa SOLUTION, INTRAVENOUS 1 gm - 0.5 gm      
Display Fifth Generation Cephalosporins Class : 08120620
Medication comments:

Refrigerator item 

Per policy, these drugs are subject to renal dosing adjustments by pharmacy. 
Generic + Route
(Brand)
• Indications		 Usual Adult Dose
Comments		 Renal Dosage Adjustments
ceftolozane-tazobactam IV
(Zerbaxa©)		 1.5 gm – 3 gm q8h
Restricted to ID only!		 CrCl > 50: No adjustment necessary
CrCl 30 - 50: 750 mg – 1.5 gm q8h
CrCl 15 - 29: 375 mg – 750 mg q8h
CrCl < 15: no dosage adjustment provided by mfg
HD/PD: 750 mg – 2.25 gm x1 then 150 mg – 450 mg q8h; Administer dose immediately after dialysis on dialysis days
Last updated: Sep. 3, 2025
UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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