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cefTRIAXone

cefTRIAXone
Drug Name Form Strength Non-Formulary Restricted TX Sub Notes
Rocephin POWDER FOR INJECTION, INJECTABLE 250 mg; 500 mg; 1 g; 2 g      
Display Third Generation Cephalosporins Class : 08120612
Medication comments:

ceftriaxone (Rocephin) dilution volumes for IM injections, using SWFI, NS, or lidocaine 1%
to prepare 250 mg/ml solution vial volume   to prepare 350 mg/ml solution vial volume
250 mg 0.9 mL 500 mg  1 mL
500 mg 1.8 mL  1 gm 2.1 mL
 1 gm 3.6 mL  2 gm 4.2 mL
 2 gm 7.2 mL  
Per policy, these drugs are subject to renal dosing adjustments by pharmacy. 
Generic + Route
(Brand)
• Indications		 Usual Adult Dose
Comments		 Renal Dosage Adjustments
cefTRIAXone IV/IM
(Rocephin©)		 1-2 gm q24h No adjustment necessary
 Per policy, these antibiotic medications may be given IV push.  Adult Patients Only!
generic (Brand) Strength Copy/Paste comments for PharmNet
cefTRIAXone (Rocephin) 1 gm vial Dilute with 10 ml Sterile Water for Injection and give over 2-4 mins.
cefTRIAXone (Rocephin) 2 gm vial Dilute with 20 ml Sterile Water for Injection and give over 2-4 mins.
Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics 
Medication: cefTRIAXone (Rocephin)
Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List: Second Edition (Table 1)
Drug cefTRIAXone
Risk/Rationale Kernicterus
Recommendation Caution in younger than 3 wk except for one-time doses for gonococcal treatment
 Quality of evidence: Very low, Strength of Recommendation: Weak
Last updated: Sep. 25, 2025
  • Renal Adjustment Policy cefTRIAXone subject to adjustments by pharmacy.
  • Look-Alike/Sound-Alike cefTRIAXone confused with ceFAZolin, cefoTEtan, cefOXitin, cefTAZidime
UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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