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acyclovir

acyclovir

Drug Name	Form	Strength
Zovirax	CAPSULE, ORAL	200 mg
Zovirax	SOLUTION, INTRAVENOUS	50 mg/mL
Zovirax	TABLET, ORAL	800 mg

Display Nucleosides and Nucleotides Class : 081832

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
acyclovir IV (Zovirax^©) • Herpes Zoster • HSV encephalitis	10 mg/kg q8h Actual weight, use IBW for obese pts (BMI > 30)	CrCl > 50: No adjustment necessary CrCl 25-50: 10 mg/kg q12h CrCl 10-24.5: 10 mg/kg q24h CrCl < 10: 5 mg/kg q24h HD/PD: 2.5-5 mg/kg q24h
acyclovir IV (Zovirax^©) • Herpes Simplex	5 mg/kg q8h Actual weight, use IBW for obese pts (BMI > 30)	CrCl > 50: No adjustment necessary CrCl 25-50: 5 mg/kg q12h CrCl 10-24.5: 5 mg/kg q24h CrCl < 10: 2.5 mg/kg q24h HD/PD: 2.5-5 mg/kg q24h
acyclovir PO (Zovirax^©)	200-800 mg 5x/day	CrCl > 25: No adjustment necessary CrCl 10-25: 200-800 mg q8h CrCl < 10: 200 mg q12h HD: 200 mg q12h PD: 600-800 mg daily

Adult Extravasation Management
acyclovir (Zovirax)

Agent type:	Non-Chemotherapeutic
Vesicant/Irritant:	Irritant (at conc > 7mg/mL)
Local Care:	Dry warm compresses
Antidote:	Hyaluronidase (may consider for refractory cases in addition to supportive measures)
Antidote link(s):
Comments:	• Irritant with vesicant-like properties

Enteral Drug Administration notes.
Generic (Brand)	Comments and Considerations	Recommendations for Administration with Enteral Nutrition
acyclovir (Zovirax)	Commercially available suspension combined with Osmolite resulted in clogging 8 Fr, but not 20 Fr feeding tubes	Disperse tablet in 20 mL water. Do NOT administer suspension through feeding tube.

Last updated: Jun. 18, 2025

Renal Adjustment Policy acyclovir subject to adjustments by pharmacy.

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

This site is intended for the staff of Iredell Health System. While others may view accessible pages, Iredell Health System makes no warranty, express or implied, as to the use of this information outside of Iredell Health System. The content of this policy and procedure document serves as guidance to the delivery of quality patient care. Care providers are expected to exercise critical thinking and situational awareness skills, and in specific situations to take such action as is necessary for the delivery of quality patient care.