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Huntsville Hospital

Approved Hospital Formulary

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Medications not yet evaluated by P&T are considered NON-FORMULARY. Always check 2 unique patient identifiers - NAME and DATE OF BIRTH - at every step!
Please be sure to document all clinical activities daily.

Huntsville Hospital

Approved Hospital Formulary

Suggestions or Corrections? Above and Beyond Nominations Formulary Request

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promethazine

promethazine

Formulary Not to be given IV push.
Formulary For parenteral shortage situation, see interchange to prochlorperazine (Compazine) injection below.

Drug Name	Form	Strength
Phenergan, Prorex	SOLUTION, INJECTABLE	25 mg/mL
Phenergan, Phenadoz, Promethegan	SUPPOSITORY, RECTAL	12.5 mg, 25 mg, 50 mg
Phenergan	SYRUP, ORAL	6.25 mg/5 mL
Phenergan, Promacot	TABLET, ORAL	12.5 mg, 25 mg

VIEW MORE First Generation Antihistamines, Anxiolytics, Sedatives, and Hypnotics, Miscellaneous

High Alert Drug : Policy

Comments:

Injectable form of promethazine is a HIGH-RISK/HIGH-ALERT drug - use extreme caution

Category A Vesicant: See Management of Extravasation of Irritant and Vesicant Drugs (Non-Chemotherapy) - ADULTS and Management of Extravasation of Irritant and Vesicant Drugs (Non-Chemotherapy) PEDIATRIC

Powerplans: HOSP Vesicant Extravasation Management Orders and PEDS Vesicant Extravasation Management Orders

PHENERGAN injection is allowed via IM administration. IV push administration of promethazine is banned. IF GIVEN IV, MUST BE GIVEN IVPB. CENTRAL LINE PREFERRED. USE SUPPOSITORY ROUTE WHEN POSSIBLE. As long as prochlorperazine injection is available, the pharmacist may automatically interchange orders for IV promethazine to prochlorperazine (if desired by nurse and/or patient).

Ordered Formulation	Therapeutic Interchange	Notes
prochlorperazine (Compazine) 10 mg IV/IM	ondansetron (Zofran) 4 mg IV/IM	Interchange during prochlorperazine injection shortage. Other dosages will be interchanged in a proportional ratio.
prochlorperazine (Compazine) 10 mg IV/IM	promethazine (Phenergan) 25 mg IVPB/IM	Interchange during prochlorperazine injection shortage if patient does not tolerate ondansetron. Other dosages will be interchanged in a proportional ratio.

Interchange from promethazine (Phenergan) injection to prochlorperazine (Compazine) injection during promethazine shortage.

Ordered Formulation

Therapeutic Interchange

promethazine (Phenergan, Prorex)

12.5 mg IVPB/IM

prochlorperazine (Compazine)

5 mg IV/IM

promethazine (Phenergan, Prorex)

25 mg IVPB/IM

prochlorperazine (Compazine)

10 mg IV/IM

Last updated: May. 13, 2026

Black Box Warning: Patients < 2 years; severe tissue injury
Formulary, Not Routinely Stocked: 50 mg rectal suppoistory

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