• Criteria for use of injectable methadone by palliative care/hospice
  
  • Intravenous methadone can be considered in patients who meet all of the following criteria:
    • Are unable to tolerate oral opioids or archieve adequate pain relief on oral opioids
    • Meet one of the following:
      • Have uncontrolled pain despite maximum tolerated parenteral opioids
      • Have adequate pain control and are experiencing unwanted dose-related side effect with parenteral opioids
  • Subcutaneous/intramuscular methadone can be considered in patients who meet all the following criteria:
    • Meet the criteria for intravenous methadone, as defined above
    • Lack ability to maintain or gain access to intravenous administration

Dolophine medication guide

Methadone Reference Sheet

Methadone Clinic Request for Information Form

REMS (Dolophine, Methadose, methadone): View FDA REMS Info

Reviewed February 25, 2020

Updated: November 2020

• Micromedex
• UpToDate
• Lippincott Advisor