Single Level Adjustment
Wt for Vd:
(uses Adj.BW unless pt weighs < IBW)
Wt for CrCl:
(uses IBW unless pt weighs < IBW)
(uses 0.7 if left blank)
(uses 1.5 if left blank)
Optimal AUC:MIC ratio 400 or greater.
Consider loading dose only for indications requiring a trough of 15-20. (bacteremia, osteomyelitis, pneumonia, endocarditis, meningitis).
Click here for background information.
DISCLAIMER: All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither Memorial Hospital nor any other party involved in the preparation or publication of this site shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
Last modified Oct 2020
Single Level Vancomycin Dose Adjustment
ONLY FOR USE IN PTS WITH STABLE RENAL FXN
Use "M" or "F"
Actual Weight (kg):
Minutes Before Dose*:
Predicted New Trough:
(if left blank, uses 1.5)
hrs (from time trough drawn)
Level will drop to:
A new Ke is calculated using the following equation:
ln[(dose/Vd + Trough)/Trough]
When you enter a New Dose & Interval, a peak is extrapolated:
Predicted Pk =
Dose * (1 - e
(-Ke * infusion time)
Ke * Vd * inf time * (1 - e
(-Ke * dose interval)
The extrapolated peak is then used to determine a trough with the same Ke:
Predicted Trough =
Pred Pk * e (-Ke *
(Dose interval - inf time)
Time to Hold estimations calculated as follows:
* Note: In the above equations, "Dose Interval" = "Current Interval" - "Minutes Drawn Before Dose". E.g. if the interval is 12 hours and the level is drawn 30 minutes before the dose, it will use 11.5 hours as the "Dose Interval".