Vancomycin Dosing Calculator Background Information:

·        Vd is calculated using adjusted body weight, unless patient weighs less than IBW. In that case, the actual body weight is used.

·        Vd distribution factor defaults to 0.7 if left blank, otherwise uses the value entered.

·        MIC is always 1 for AUC:MIC calculations.

·        CrCl is calculated using Cockroft-Gault. This equation uses IBW, unless the patient weighs less than IBW. In that case, the actual body weight is used.

·        Loading Doses are calculated using actual body weight. Doses are automatically rounded to the nearest 250 mg that will provide a 25-30 mg/kg load. For ease of administration, doses > 2,000 mg are rounded to either 2,500 mg or 3,000 mg. Loading dose is capped at a max dose of 3,000 mg. A split loading dose is utilized for patients requiring 2,500 or 3,000 mg doses. Click here for more information regarding our loading dose strategy.

·        Infusion length is determined according to the dose entered, based on standard rates at Memorial.

·        Ke is calculated as follows:

Ke = (0.00083 * CrCl) + 0.0044

·        Ke is then used to calculate an expected peak as follows:

·        The Ke and Predicted Pk are then used to estimate the Trough:

Double Level Adjustment Calculations

A new Ke is calculated as follows:

True peak is extrapolated as follows:
         

True min is extrapolated as follows:

AUC₂₄ is calculated as follows: